Method for labeling proteins with technetium or rhenium

Details Method for labeling proteins with technetium or rhenium Method for labeling proteins with technetium or rhenium

1988-08-25

1993-06-15

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

5303915, 5303917, 530402, 530304, 534 10, 534 14, A61K 4902, A61K 4300, C07F 1300

Patent

active

052195554

ABSTRACT:
The invention relates to a method for labeling substances with--in particular radioactive--technetium or rhenium isotopes with the aid of N-substituted or C-substituted macrocyclic amine derivatives of the formula I and/or II ##STR1## in which R.sup.1 -R.sup.7, Y, m, n, o, p, f, g, h, i and j have the stated meanings, and to the use of these labeled substances, especially in medical diagnosis.

REFERENCES:
patent: 4678667 (1987-07-01), Meares et al.
patent: 4818813 (1989-04-01), Nowotnik et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 5087696 (1992-02-01), Parker et al.
Franz, J. et al., "The Production of Tc-99m-Labeled . . . Chelating Agent", Nucl. Med. Biol., v. 14, No. 6, pp. 569-572, Jun. 1987.

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