Method for labeling antibodies with a metal ion

Details Method for labeling antibodies with a metal ion Method for labeling antibodies with a metal ion

1987-04-02

1991-10-01

Kepplinger, Esther L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530387, 530388, 530389, 530390, 436547, 436804, 514492, C07K 308, G01N 3353, A04N 5502

Patent

active

050534939

ABSTRACT:
A simple, rapid and efficient method for labelling sulfhydryl-containing antibodies or antibody fragments with Tc-99m, Rh-186, Rh-188, Rh-189 or Rh-191 is disclosed. Labeled antibodies produced by the method are useful for radio-immunodiagnostic and/or radio-therapeutic purposes.

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Richards and Steigman, Radiopharmaceuticals, Chapter 3, pp. 26-30, Subramanian, Rhodes, Cooper and Sodd, Eds., New York, Society of Nuclear Medicine (1975).

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