Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-05-15
1993-12-07
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548455, C07D20902, C07D20956
Patent
active
052684865
ABSTRACT:
A luminescent cyanine dye having generally the following structure ##STR1## wherein the dotted lines represent one to three rings having 5 to 6 atoms in each ring. R.sub.3, R.sub.4, R.sub.8 and R.sub.9 groups are attached to the rings. At least one of the R.sub.8 and R.sub.9 groups is a sulfonic acid or sulfonate group and at least one of the R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 groups is a reactive moiety that reacts with amino, hydroxy or sulfhydryl nucleophiles.
REFERENCES:
patent: 3423207 (1969-01-01), Heseltine et al.
patent: 4138551 (1979-02-01), Steiger et al.
patent: 4166105 (1979-08-01), Hirschfeld
patent: 4256834 (1981-03-01), Zuk et al.
patent: 4337063 (1982-06-01), Mihara et al.
patent: 4404289 (1983-09-01), Masuda et al.
patent: 4405711 (1983-09-01), Masuda et al.
patent: 4414325 (1983-11-01), Masuda et al.
patent: 5106990 (1992-04-01), Ohno et al.
Salama, G., et al. "Sulfhydryl Reagent Dyes Trigger the Rapid Release of Ca.sup.2+ from Sarcoplasmic Reticulum Vesicles (SR)", Biophysical Journal, vol. 47, 456a (1985).
A. S. Waggoner, et al. "The Kinetics of Conformational Changes in a Region of the Rhodopsin Molecule Away from the Retinylidene Binding Site", Biophysical Journal, vol. 33, 292a (1981).
Jacobson, et al. "International Workshop on the Application of Fluorescence Photobleaching Techniques to Problems in Cell Biology", Federation Proceedings, vol. 42, 72-79 (1973).
M. R. Loken et al., "Lymphoid Cell Analysis and Sorting", Flow cytometry and Sorting, pp. 505, 522-523, (1979).
R. M. McKinney et al. "An Approach to Quantitation in Rhodamine Isothiocyanate Labeling", Annals N.Y. Acad. of Sciences, vol. 254, pp. 55-65 (1975).
R. T. Morrison et al. "Preparation of Sulfonic Acids", Organic Chemistry, 2nd Edition, pp. 701-704 (1985).
K. A. Muirhead et al. "Flow Cytometry: Present and Future" Review, Biotechnology, vol. 3 (Apr. 1985).
J. S. Ploem "General Introduction" Fifth International Conference on Immunofluorescence and Related Staining Techniques, Annals of the N.Y. Academy of Sciences, vol. 254, pp. 1-20 (1975).
R. P. Haugland, "Covalent Fluorescent Probes" Excited States of Biopolymers, Plenum Press pp. 29-58 (1982).
F. Hamer, Cyanine Dyes and Related Compounds, Interscience Publishers, pp. 86-350, 398-399, 460-463, 482-495 and 511-513, (1964).
Ernst Lauren A.
Mujumdar Ratnakar B.
Waggoner Alan S.
Carnegie-Mellon Unversity
Grumbling Matthew V.
Shah Mukund J.
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