Chemistry: analytical and immunological testing – Including use of radioactive properties
Patent
1988-07-26
1990-12-04
Warden, Robert J.
Chemistry: analytical and immunological testing
Including use of radioactive properties
436161, 422 70, 422 71, 210635, 210656, G01N 2300, G01N 2306, G01N 3002, B01D 1503
Patent
active
049753789
ABSTRACT:
Method for integrating isotope dilution analysis with chromatography. One embodiment of the invention includes a liquid chromatographic column, a radiochemical detector, an eluent that contains an additive at saturation and a radiochemically labeled derivative of the analyte to be determined. When the analyte, which is not radioactive, is injected, its movement through the column occurs more slowly than the movement of the radioactive derivative situated on the column outside the analyte band. As a result, radioactivity enters the analyte band and isotope dilution occurs. The distribution of radioactivity within the band is used to determine the amount of analyte injected.
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Vassilatos Thalia P.
Warden Robert J.
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