Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-02-10
1999-06-15
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435971, 5303887, 5303896, G01N 33567, G01N 33537, C07K 1628, C12P 2108
Patent
active
059121335
ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
REFERENCES:
patent: 5061620 (1991-10-01), Tsukamoto
patent: 5130144 (1992-07-01), Civin
Chan Christina Y.
Feit Irving N.
Rabin Evelyn
The Trustees of Princeton University
LandOfFree
Method for isolating stem cells expressing flk-1 receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for isolating stem cells expressing flk-1 receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for isolating stem cells expressing flk-1 receptors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-401893