Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-04
2007-09-04
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S567000
Reexamination Certificate
active
10841075
ABSTRACT:
(R)-tofisopam, substantially free of the (S)-enantiomer of tofisopam, is obtained by separating the enantiomers of tofisopam by chromatography employing a chiral separation medium comprising (i) (2S)-2-{(1S)[(3,5-dinitrophenyl)carbonylamino]phenylmethyl}-3,3-dimethylbutanoate, covalently bound to silica through an alkylene ester linkage or (ii) an amylose derivative of formula I:wherein each R1and n are defined herein; the amylose derivative being coated on a porous inorganic carrier or a porous organic carrier.
REFERENCES:
patent: 5202433 (1993-04-01), Okamoto et al.
patent: 6080736 (2000-06-01), Landry
patent: 6638928 (2003-10-01), Harris et al.
patent: 6864251 (2005-03-01), Kucharik et al.
patent: 7022700 (2006-04-01), Harris et al.
patent: 2004/0152695 (2004-08-01), Harris et al.
patent: 2004/0157833 (2004-08-01), Harris et al.
patent: 178516 (1983-03-01), None
patent: WO 02/094189 (2002-11-01), None
Bargmann-Leyder et al., A Comparison of LC and SFC for Cellulose- and Amylose- Derived Chiral Stationary Phases, Chirality, vol. 7, No. 5, pp. 311-325, 1995.
M. Simonyi et al., “Stereoselective Binding of a 2,3-Benzodiazepine to Human Serum Albumin”, Biochemical Pharmacology. vol. 32, No. 12, pp. 1917-1920, 1983.
J. Visy et al., “The Role of Configuration and Conformation in the Binding of 2,3-Benzodiazepines to Human Serum Albumin”, CHIRALITY 1:271-275 (1989)..
M. Rizzo, “Chromatographic separation of 2,3-benzodiazepines”, Journal of Chromatography B, 747 (2000) 203-216.
B. Chankvetadze et al., “Dimethyl-, dichloro- and chloromethylphenylcarbamates of amylase as chiral stationary phases for high-performance liquid chromatography”, Journal of Chromatography A, 694 (1995) 101-109.
“Whelk-O 1 Chiral Stationary Phase for many Enantioseparations”, VWR International Ltd, 2000, '01, '02, '03; http://www.chromatography.co.us/APPS/HPCL/WHELKAPP.HTM, downloaded Apr. 14, 2003.
Geoffrey Cox, Ph.D. et al., “New High Performance Amylose Chiral Columns: CHIRALPAK AS-H and CHIRALPAK AS-RH”, The Application Notebook (Jun. 2002).
Chromatography Catalog, pp. 16-28, Regis Technologies, Inc. (2002).
Galbraith Kimm B.
Perrin Scott R.
Ye Naidong
Coleman Brenda
Drinker Biddle & Reath LLP
Monaco Daniel A.
Vela Aquisition Corporation
LandOfFree
Method for isolating ( R )-tofisopam does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for isolating ( R )-tofisopam, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for isolating ( R )-tofisopam will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3758209