Method for isolating polyether antibiotics

Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Processes of making – purifying or recovering

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536 17R, A61K 3500, C07H 1522

Patent

active

042139660

ABSTRACT:
A method is provided for recovering a polyether antibiotic, such as lonomycin, monensin or ionomycin from a fermentation broth, wherein the polyether is first extracted with a water-immiscible solvent, such as ethyl acetate, and the resulting extracts concentrated, dissolved in aqueous methanol and then extracted into hexane, benzene or mixtures thereof. The polyether is thereby recovered in crystalline form directly from the latter extract.

REFERENCES:
patent: 3476856 (1969-11-01), Kulbakh et al.
patent: 3873693 (1975-03-01), Meyers et al.
Omura et al., J. Antibiotics, XXIX, No. 1 (1976), pp. 15-20.

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