Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-11-01
2005-11-01
Gambel, Phillip (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S002000, C435S007100, C435S007240, C435S375000, C435S377000
Reexamination Certificate
active
06960446
ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG.1a(murine flk-2), FIG.1b(human flk-2) and FIG.2(murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG.1a, FIG.1band FIG.2;ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
REFERENCES:
patent: 4714680 (1987-12-01), Civin
patent: 4965204 (1990-10-01), Civin
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5130144 (1992-07-01), Civin
patent: 5185438 (1993-02-01), Lemischka
patent: 5270458 (1993-12-01), Lemischka
patent: 5283354 (1994-02-01), Lemischka
patent: 5367057 (1994-11-01), Lemischka
patent: 5621090 (1997-04-01), Lemischka et al.
patent: 5912133 (1999-06-01), Lemischka
patent: 0 317 156 (1989-05-01), None
patent: 0 330 191 (1989-08-01), None
patent: 0 395 355 (1990-10-01), None
patent: WO 92/14748 (1992-09-01), None
Lederman et al. Mol. Immunol. 11: 1171-1181 (1991).
Li et al. PNAS 77: 3211-3214 (1980).
Skolnick et al. Tibtech 18: 34-38 (2000).
Ngo et al. In the Protein Folding Problem and Tertiary Structure Prediction Edited by Merz and Le Grand, Birkhauser, Boston 1994, pages.
Dexter & Spooncer, Annual Review of Cell Biology 3, (1987), pp. 423-441.
Copeland et al., Cell 63 (1990), pp. 175-183.
Hanks et al., Science 241 (1988), pp. 42-52.
Wilks, Proc. Natl. Acad. Sci. USA 86 (1989), pp. 1603-1607.
Hopp et al., Proc. Natl. Acad. Sci. USA 78, (1981), pp. 3824-3828.
Jordan et al., Cell 61 (1990), pp. 953-963.
Ikuta et al., Cell 62 (1990), pp. 863-864.
Spangrude et al., Science 241 (1988), pp. 58-62.
Szilvassy et al., Blood 74 (1989), pp. 930-939.
Andrews et al., Journal of Experimental Medicine 169 (1989), pp. 1721-1731.
Flanagan et al., Cell 63 (1990), pp. 185-194.
Hammerschmidt et al., Nature 340 (1989), pp. 393-397.
Abcouwer et al., Biotechnology 7 (1989), pp. 939-946.
Matthews et al., Cell 65 (1991), pp. 1143-1152.
Civin, Exp. Hematol. 15 (1987), pp. 10-17.
Rosnet et al., Oncogene 6 (1991), pp. 1641-1650.
Rosnet et al., Genomics 9 (1991) pp. 380-385.
Terman et al., Oncogene 6 (1991) pp. 1676-1683.
Lemischka et al., Cell 45 (1986), pp. 917-927.
Williams et al., Cell 63 (1990), pp. 163-174.
Zsebo et al., Cell 63 (1990), pp. 195-201.
Martin et al., Cell 63 (1990), pp. 203-211.
Zsebo et al., Cell 63 (1990), pp. 213-224.
Orr, Genetic Engineering News, (Feb. 1991), p. 8.
Batuman et al., Journal of Immunology 130 (1983), pp. 1051-1055.
Streeten et al., Proc. Nat'l. Acad. Sci. 86 (1989), pp. 916-920.
Zipori, Int'l. Journal of Cell Cloning 7 (1989), pp. 281-291.
Kabrun et al., Development 124 (1997), pp. 2039-2048.
Loken et al., Blood 69 (Jan. 1987), pp. 255-263.
Suda et al., Int'l Journal of Hematology 71 (2000), pp. 99-107.
Bolen et al., FASEB 6, (1992), pp. 3403-3409.
Jones et al., Proc. Nat'l Acad. Sci, USA 85 (1988), pp. 3377-3381.
Matthews et al., PNAS 88:9026-9030, Oct. 1991.
Millauer et al., Cell 72:835-846, 1993.
Nakamura, et al, “Ex Vivo Generation of CD34+ cells from CD34- Hematopoietic cells” Blood, Dec. 15, 1999, vol. 94, No. 12, pp. 4053-4059.
Nocka et al., “Candidate ligand for the C-kit transmembrane Kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors” vol. 9, No. 10, pp. 3287-3294, 1990.
Nocka, K. et al., “Expression of C-Kit gene products in known cellular targets of W mutations in normal and W mutant mice-evidence for an impaired C-Kit Kinase in mutant mice, Genes and Development” vol. 3, No. 6, pp. 739-920, 1989.
Peichev, et al., “Expression of VEGFR-3 and AC133 by circulating human CD34 Cells identifies a population of functional endothelial precursors” Blood, Feb. 1, 2000, vol. 95, No. 3, 953-958.
Sarzani et al., Biochem Biophys Res Comm. 186(2) 706-714 Jul. 31, 1992.
Terman et al., Biochem Biophys Res Comm. 187(3) 1579, 1992.
Wek et al., Proc. Nat'l Acad. Sci, USA 86, (1989), pp. 4579-4583.
Wilks PNAS 86:1603-1607 Mar. 1989.
Yamaguchi, et al., “flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors” Development 118, 489-498, 1993.
Yang et al., J. Neuroscience 16:6089-6099, 1996.
Gambel Phillip
The Trustees of Princeton University
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