Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1990-04-11
1994-03-08
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530395, 530394, 530380, 530350, 530400, 530412, 530414, 424 92, A61K 39095, A61K 3904, A61K 3902, C07C10352
Patent
active
052928691
ABSTRACT:
The present invention relates to a method for isolating and purifying transferrin and lactoferrin receptor proteins from bacterial pathogens by affinity chromatography and to the preparation of vaccine antigens containing the purified receptor proteins.
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Schryvers and Morris, Identification and Characterization of the Transferrin receptor from Neisseria meningiti Mol. Microbiol. 2(2), 281-88, 1988.
Lee and Schryvers, Specificity of the lactoferrin and transferrin receptors in Neisseria gonorrhoeae Mol. Microbiol. 2(6) pp. 827-829, 1988.
Ala'Aldeen, et al., Seventh International Pathogenic Neisseria Conference, Sep. 9-14, 1990 West Berlin.
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Schryvers, A. B., "Identification of the Transferrin- and Lactoferrin-binding Proteins in Haemophilus Influenzae"; J. Med. Microbiol., vol. 29 (1989), 121-130.
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The Thesis of Leigh J. Morris, 1988, at the University of Calgary "Meningococcal Receptors for Transferrins", pp. 1-186.
Schain Howard E.
The Board of Governors of the University
Touzeau P. Lynn
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