Method for isolating and purifying...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C564S339000, C548S211000

Reexamination Certificate

active

06909017

ABSTRACT:
The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol as a saccharinate from a mixture of the diastereomers (1SR,2)RS-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol and (1SR-2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol and optionally impurities.

REFERENCES:
patent: 3652589 (1972-03-01), Flick et al.
patent: 5672755 (1997-09-01), Lerman et al.
patent: 5877351 (1999-03-01), Anderson
patent: 19940740 (2001-03-01), None
patent: WO 99/61405 (1999-12-01), None
patent: WO 00/78705 (2000-12-01), None
“Solvatochromic Dyes As Solvent Polarity Indicators”, Reichardt, Chem. Rev. 1994, 94, pp. 2319-2358.
“Determination Of New And Corrections of Old ET(30) Values As Empirical Measures Of Solvent Polarity For 40 Organic Solvents”, Reichardt et al., Liebigs Ann., 1995, pp. 1579-1582.
R. Eberhardt et al., “Determination of ET(30) Values of Supercritical Carbon Dioxide at Various Pressures and Temperatures” 1997, Germany, pp. 1195-1199.

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