Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-09-01
1995-04-04
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530412, 514 2, C07K 1506, A61K 3702
Patent
active
054038251
ABSTRACT:
Described is a purified osteogenic factor that when delivered to bone in association with a physiologically acceptable delivery vehicle is capable of inducing new bone growth at the bone surface. The osteogenic factor is water soluble, and is characterized physically by a molecular weight of about 2.5 kD when measured by gel filtration under dissociating conditions and an isoelectric point in the pH range from about 4.6 to 7.2. Use of the purified factor in treating bone defects is described. Also described is a method for obtaining the purified factor from mammalian bone.
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patent: 4563350 (1986-01-01), Nathan
patent: 4627982 (1986-12-01), Seyedin
patent: 5169837 (1992-12-01), Lagarde
Tornberg, et al., "Activation of the Resting Periosteum", Clinical Orthopaedics and Related Research, vol. 129, Nov.-Dec. 1977, pp. 305-312.
Clark, et al., "Bone-Cell-Stimulating Substance", Clinical Orthopaedics and Related Research, vol. 237, Dec. 1988, pp. 226-235.
Abdulwajid Abdulwahid
Bueschkens Donna
Byrne Deanna
Lagarde Alain E.
Allelix Biopharmaceuticals Inc.
Hill Jr. Robert J.
Salata Carol
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