Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-10-14
1997-02-04
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 691, 4352523, 43525233, 43525411, 4353201, 435 911, 536 231, 5303871, 935 79, C12Q 102, C12N 1512, C07K 1600
Patent
active
055996760
ABSTRACT:
The present invention is directed to a method for isolating a novel receptor for .alpha.4 integrins such as VLA-4, that is distinct from VCAM-1 and from fibronectin. Isolated nucleic acids encoding the receptor and antibodies to the receptor are also provided. The invention is also directed to pharmaceutical compositions, and methods of treating disorders involving an undesirable inflammatory or immune response by administering the VLA-4 receptor of the invention.
REFERENCES:
Aruffo and Seed, 1987, "Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system," Proc. Natl. Acad. Sci. USA 84:8573-8577.
Mizushima and Nagata, 1990, "pEF-BOS, a powerful mammalian expression vector," Nucl. Acids Res. 18(17):5322.
Sambrook and Gething, 1988, "Vectors for high level expression of proteins in mammalian cells," Focus 10(3):41-48.
Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual, 2d ed., Cold Spring Harbor Laboratory Press, New York, pp. 16.17-16.22, 16.69, and 16.73-16.81.
Seed, 1987, "An LFA-3 cDNA encodes a phospholopid-linked membrane protein homologous to its receptor CD2," Nature 329:840-842.
Seed and Aruffo, 1987, "Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure," Proc. Natl. Acad. Sci. USA 84:3365-3369.
Simmons and Seed, 1988, "Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells," J. Immunol. 141:2797-2800.
Wong et al., 1985, "Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins," Science 228:810-815.
Yang et al., 1986, "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3," Cell 47:3-10.
Chan, et al., 1992, Adhesion to vascular cell adhesion molecule 1 and fibronectin comparison of .alpha..sup.4 .beta..sub.1 (VLA-4) and .alpha..sup.4 .beta..sub.7 on the human B cell line JY, J. Biol. Chem. 267:8366-8370.
Hemler, et al., 1987, Characterization of the cell surface heterodimer VLA-4 and related peptides, J. Biol. Chem. 262:11478-11485.
Elices, et al., 1990, VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site, Cell 60:577-584.
Shimizu, et al., 1990, Regulated expression and binding of three VLA (.beta.l) integrin receptors on T cells, Nature 345:250-253.
Chan, et al., 1992, Distinct cellular functions mediated by different VLA integrin .alpha. subunit cytoplasmic domains, Cell 68:1051-1060.
Staunton, et al., 1989, Functional cloning of ICAM-2, a cell adhesion ligand of LFA-1 homologous to ICAM-1, Nature 339:61-64.
de Fougerolles, et al., 1991, Characterization of ICAM-2 and evidence for a third counter-receptor fo LFA-1, J. Exp. Med. 174:253-267.
de Fougerolles and Springer, 1992, Intercellular adhesion molecule 3, a third adhesion counter receptor for lymphocyte function-associated molecule 1 on resting lymphocytes, J. Exp. Med. 175:185-190.
Springer, 1990, Adhesion receptors of the immune system, Nature 346:425-433.
Pober and Cotran, 1990, The role of endothelial cells in inflammation, Transplantation 50:537-544.
Dustin and Springer, 1988, Lumphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells, J. Cell. Biol. 107:312-331.
Schwartz et al., 1990, Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium. J. Clin. Invest. 85:2019-2022.
Pober et al., 1986, Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol. 137(6): 1893-1896.
Kishimoto et al., 1989, The leukocyte integrins, Adv. Immunol. 46:149-182.
Springer et al., 1987, The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: Cell adhesion receptors of the Immune System, Ann. Rev. Immunol. 5:223-252.
Carlos et al., 1990, Membrane proteins involved in phagocyte adherence to endothelium, Immunol. Rev. 114:5-28.
Osborn et al., 1989 Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes, Cell 59:1203-1211.
Wellicome et al., 1990, A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide, J. Immunol. 144:2558-2565.
Rice et al., 1990, Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes, J. Exp. Med. 171:1369-1374.
Carlos, et al. 1990, Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells, Blood 76:965-970.
Guan and Hynes, 1990, Lymphoid cells recognize alternatively spliced segment of fibronectin via the integrin receptor .alpha..sub.4 .beta..sub.1, Cell 60:53-61.
Wayner et al., 1989 Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin, J. Cell Biol. 109:1321-1330.
Hemler, 1990, VLA proteins in the integrin family: structures, functions, and their role on leukocytes, Ann. Rev. Immunol 8:365-400.
Clayberger et al., 1987, Identification and characterization of two novel lymphocyte function-associated antigens L24 and L25. J. Immunol. 138(5):1510-1514.
Miyake et al., 1991, Evidence for a role of the Integrin VLA-4 in lympho-hemopoiesis. J. Exp. Med. 173:599-607.
Williams et al., 1991, Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature 352:438-441.
Miyake et al., 1991, A VCAM-like adhesion molecule on murine bone marrow stromal cell mediates binding of lymphocyte precursors in culture. J. Cell. Biol. 114(3):557-565.
Ryan et al., 1991, Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells, J. Clin. Invest 88:995-1004.
Freeman et al., 1990, Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science 249:1030-1033.
Taichman et al., 1991, Tumor cell surface .alpha..sup.4 .beta..sub.1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1. Cell. Reg. 2:347-355.
Rice and Bevilacqua, 1989, An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science 246:1303-1306.
Cybulsky and Gimbrone, 1991, Endothelial expression of a mononuclear leukocyte adhesion molecule during antherogenesis. Science 251:788-791.
Briscoe et al., 1991, Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts, Transplantation 51:537-547.
Cybulsky et al., 1991, Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM.sub.1 gene. Proc. Natl. Acad. Sci. USA. 88:7859-7863.
Polte et al., 1990, Full length vascular cell adhesion molecule 1 (VCAM-1), Nucl. Acids. Res. 18:5901.
Cybulsky et al., 1991, Alternative splicing of human VCAM-1 in activated vascular endothelium, Amer. J. of Path. 138:815-820.
Hession et al., 1991, Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1), J. Biol. Chem. 266:6682-6685.
Rothlein et al., 1986, A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol 137(4): 1270-1274.
Makgoba et al., 1988, Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity, Eur. J. Immunol 18:637-640.
Oppenheimer-Marks et al., 1991, Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes, J. Immunol 147(9):2913-2921.
Anderson and Springer, 1987, Leukocyte adhesion deficiency: an inherited defet in the Mac-1, LFA-1, and p 150,95 glycoproteins, Ann. Rev. Med. 38:175-194.
Graber et al., 1990, T cells bind to cytokine-activated endothelial cells via a novel, inducible sialogl
Springer Timothy A.
Vonderheide Robert H.
Center For Blood Research, Inc.
Teng Sally P.
Walsh Stephen G.
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