Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1993-12-14
1996-03-19
Rosenbaum, C. Fred
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 21, A61N 130
Patent
active
054999715
ABSTRACT:
A drug delivery apparatus and method for iontophoretically delivering a drug locally to internal body tissue. The iontophoretic delivery apparatus and method include a current source producing a net flow of current in a desired direction with high frequency waveforms which enhance delivery and minimize side effects typically associated with iontophoresis.
The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is iontophoretically transported across a drug transport wall of the device for direct contact with the passageway wall or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by iontophoretic delivery of the drug to the tumor or tissue area directly or through the passageway wall.
REFERENCES:
patent: 3542014 (1970-11-01), Peronneau
patent: 3886950 (1975-06-01), Ukkestad et al.
patent: 4456012 (1984-06-01), Lattin
patent: 4787888 (1988-11-01), Fox
patent: 4936281 (1990-06-01), Stasz
patent: 4976711 (1990-12-01), Parins et al.
patent: 5041107 (1991-08-01), Heil, Jr.
patent: 5042975 (1991-08-01), Chien et al.
patent: 5047028 (1991-09-01), Qian
patent: 5087243 (1992-02-01), Avitall
patent: 5236413 (1993-08-01), Feiring
T. Bagniefski et al., "A Comparison of Pulsed and Continuous Current Iontophoresis," Journal of Controlled Release, 11 (1990), pp. 113-122.
L. A. Geddes et al. "Response to Passage of Electric Current Through the Body," Journal of the Association for the Advancement of Medical Instrumentation, vol. 5, No. 1, Jan. Feb. 1971.
Copy of International Search Report for PCT/US92/10805.
Medical Instrumentation, The Mechanism Underlying Sudden Death from Electric Shock, L. A. Geddes, ME, Ph.D., FACC, J. D. Bourland, Ph.D. and G. Ford, EE, Nov.-Dec. 1986, vol. 20, No. 6, pp. 303-315.
Hildebrandt Keith R.
Knudson Mark B.
Shapland James E.
Bockelman Mark
CorTrak Medical Inc.
Rosenbaum C. Fred
LandOfFree
Method for iontophoretically delivering drug adjacent to a heart does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for iontophoretically delivering drug adjacent to a heart, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for iontophoretically delivering drug adjacent to a heart will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1956306