Method for inversion of optically active 4-hydroxy-2-cyclopenten

Details Method for inversion of optically active 4-hydroxy-2-cyclopenten Method for inversion of optically active 4-hydroxy-2-cyclopenten

1985-07-25

1987-07-28

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

568352, C07C14368

Patent

active

046833234

ABSTRACT:
By hydrolyzing a sulfonic acid ester or a nitric acid ester of an optically active 4-hydroxy-2-cyclopentenone, the steric inversion of the hydroxyl group at the 4-position of the cyclopentenone mentioned above is effected.
4-hydroxy-2-cyclopentenone is useful as a raw material of prostaglandins (natural substance is an (R)-substance) having stimulative action to uterine muscle and vasodilator action. For instance, 4(S)-hydroxy-2-cyclopentenone can be configurationally inverted to R-isomer. Accordingly, this method is extremely meaningful in the synthesis of prostaglandins.

REFERENCES:
patent: 4111994 (1978-09-01), Martel et al.
patent: 4132726 (1979-01-01), Kurozumi et al.
patent: 4205008 (1980-05-01), Martel et al.
patent: 4367340 (1983-01-01), Rickards et al.
patent: 4385186 (1983-05-01), Matsuo et al.
patent: 4552703 (1985-11-01), Umemura et al.
patent: 4571436 (1986-02-01), Umemura et al.
Greene, Protective Groups in Organic Synthesis, pp. ix, 913, 10-13, 107, 299 and 307 (1981).

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