Method for introducing oxygen-17 into tissue for imaging in a ma

Details Method for introducing oxygen-17 into tissue for imaging in a ma Method for introducing oxygen-17 into tissue for imaging in a ma

1988-08-19

1991-02-26

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128654, 128653, G01N 2400, A61B 600

Patent

active

049960415

ABSTRACT:
A diagnostic imaging agent is provided for use in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in tissue. The imaging agent is comprised of a complex of oxygen-17, a biologically acceptable liquid carrier, such as a perfluorinated compound, and an emulsifying agent, and wherein the agent has an average particle size of less than about 0.6 microns, and an ionic composition essentially equal to that of blood. Useful information can be obtained, and in certain instances, therapy administered, by a non-envasive imaging technique relative to tissue perfusion by .sup.19 F-NMR (imaging of .sup.19 F) and oxygen utilization by .sup.1 H-NMR (imaging of H.sub.2.sup.17 O as a metabolite).

REFERENCES:
patent: 4586511 (1986-05-01), Clark, Jr.
patent: 4775522 (1988-10-01), Clark, Jr.

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