Method for interfacing liquid chromatography-mass spectrometry s

Details Method for interfacing liquid chromatography-mass spectrometry s Method for interfacing liquid chromatography-mass spectrometry s

1994-10-19

1995-09-05

Therkorn, Ernest G.

Gas separation: processes

Difference in molecular velocity, density, or momentum of...

Passing gases through nozzle

95 82, 95267, 210656, 2101982, 250288, B01D 1508

Patent

active

054475538

ABSTRACT:
Close coupled momentum separator with integral removable source volume for particle beam liquid chromatography/mass spectrometry is provided. The inventive PB LC/MS system comprises a momentum separator wherein the skimmers are designed to accommodate the particle beam conical dispersion so as to minimize the number of particles lost in the separator. In addition, the exit of the momentum separator is closely coupled to the entrance of the MS source volume. The PB LC/MS system demonstrates improved linearity in signal and enhanced sensitivity.

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Willoughby, "Monodisperse Aerosol Generation Interface for Combining Liquid Chromatography with Mass Spectrometry," Anal. Chem., 56, 1984, pp. 2626-2631.

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