Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1993-08-09
1995-02-21
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558169, 558170, C07F 9113
Patent
active
053918002
ABSTRACT:
A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
REFERENCES:
patent: 5110987 (1992-05-01), Liotta et al.
"Enzymatic Quantificatin of Sphingosine in the Picomole Range in Cultured Cells", Van Veldhoven, et al., Analytical Biochemistry 183, 177-189 (1989).
Chemical Abstracts 1980, 92(5), No. 41295; Bushnev, A. S. et al. Bioorg. Khim. 1979, 5(9), 1381-1384.
Hakomori Sen-itiroh
Igarashi Yasuyuki
Kawa Shigeyuki
Ruan Fuqiang
Sadahira Yoshito
Ambrose Michael G.
Lee Mary C.
The Biomembrane Institute
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