Method for inhibiting transplant rejection

Details Method for inhibiting transplant rejection Method for inhibiting transplant rejection

2000-02-18

2009-02-03

Afremova, Vera (Department: 1657)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C435S325000, C435S366000

Reexamination Certificate

active

07485293

ABSTRACT:
A method for inhibiting rejection of tissues transplanted into a mammalian host is disclosed. Treatment of the tissues with an enzyme or combination of enzyme, particularly papain, to eliminate cell surface structures necessary for recognition by the host's immune system, particularly MHC Class I molecules, avoids or reduces the attack of the host's immune system on the transplanted tissues. Tissues that are enzymatically shaved of MHC Class I antigens and/or other critical adhesion molecules can be rendered at least temporarily resistant or immune to attack by cytolytic T lymphocytes, helper T lymphocytes, antibodies, or other effector cells of a host's immune system, thereby enhancing the survivability of the tissues in the host after transplant.

REFERENCES:
patent: 4383832 (1983-05-01), Fraefel et al.
patent: 4399123 (1983-08-01), Oliver et al.
patent: 5081030 (1992-01-01), Civin
patent: 5283058 (1994-02-01), Faustman
patent: 5397353 (1995-03-01), Oliver et al.
patent: 5413923 (1995-05-01), Kucherlapati et al.
patent: 5416260 (1995-05-01), Koller et al.
patent: 5670358 (1997-09-01), Lee et al.
patent: 6110206 (2000-08-01), Stone
patent: 6156306 (2000-12-01), Brownlee et al.
patent: 6322593 (2001-11-01), Pathak et al.
patent: 6617171 (2003-09-01), Faustman et al.
patent: 0 664 337 (1995-07-01), None
patent: WO 94/16065 (1994-07-01), None
patent: WO 97/08328 (1997-03-01), None
patent: WO 00/38708 (2000-07-01), None
Gallaghet et al. Clinical and Experimental Immunology (Oct. 1986) 666 (1) 118-125.
Abbas et al. Cellular and Molecular Immunology. 5th edition (2003), pp. 78-80.
Arnon,Methods in Enzymology, 19: 226-244 (1970).
Ashton-Rickardt et al.,Cell, 76: 651-663 (1994).
Bellelli et al.,Invasion Metastasis, 10:142-169 (1990).
Coffman et al.,The Journal of Immunology, 151: 425-435 (1993).
Distler and Jourdian,The Journal of Biological Chemistry, 248: 6772-6780 (1973).
Faustman and Coe,Science, 252: 1700-1702 (1991).
Galati et al.,Cytometry, 27: 77-83 (1997).
Goldstein,Transfusion Medicine Reviews, 3: 206-212 (1989).
Graff et al.,Transplantation, 4: 425-437 (1966).
Green,Microbiology Immunology, 47: 321-330 (1989).
Hogquist et al.,Cell, 76: 17-27 (1994).
Janeway, Jr.,Immunity, 1: 3-6 (1994).
Klein et al.,Transplantation, 22: 384-390 (1976).
Lafferty et al.,Science, 188: 259-261 (1975).
Lehmann et al.,Nephrol Dial Transplant, 11: 953-955 (1996).
Li and Faustman,Transplantation, 55: 940-946 (1993).
Low,Biochem, J., 244: 1-13 (1987).
Markmann et al.,Transplantation, 54: 1085-1089 (1992).
Sandrin et al.,Proc. Natl. Acad. Sci. USA, 90:11391-11395 (1993).
Sebzda et al.,Science, 263: 1615-1618 (1994).
Sigmon,Journal of Clinical Apheresis, 7: 158-162 (1992).
Snell,Annual Review of Microbiology, 2: 439-457 (1957).
Stock et al.,Journal of Surgical Research, 46: 317-321 (1989).
Stockell and Smith,J. Biol. Chem., 227: 1-26 (1956).
Stone et al.,Transplantation, 65: 1577-1583 (1998).
Watkins et al.,Transplantation Proceedings, 23: 360-364 (1991).
Sumimoto et al.,Transplantation Proceedings, 23(3): 2012-2016 (1991).
Wiman et al.,Biochemistry, 21: 5351-5358 (1982).

Affiliated with

Also associated with

Rating

Method for inhibiting transplant rejection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for inhibiting transplant rejection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting transplant rejection will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4090564