Surgery – Miscellaneous – Methods
Patent
1996-05-16
1998-11-24
Yu, Mickey
Surgery
Miscellaneous
Methods
435 13, A61B 1900
Patent
active
058394435
ABSTRACT:
This invention provides an assay to monitor antithrombic activity of a Factor IXa compound infused into circulation of a patient which includes: (a) obtaining Factor IXa-deficient plasma; (b) mixing the plasma from step (a) with diatomaceous and with plasma from the patient; (c) incubating the mixture with a source of lipid and calcium chloride under conditions suitable for clot formation; and (d) measuring time necessary for clot formation in the incubate, thereby monitoring the antithrombic activity of the Factor IXa compound infused into the circulation of the patient.
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Benedict, C.R., et al. (1994) "Endothelial-Dependent Procoagulant and Anticoagulant Mechanisms, Recent Advances in Understanding", Texas Heart Institute Journal 21: 86-90.
Kirchhofer, Daniel et al. (1995) "Active Site-Blocked Factors VIIa and Ixa Differentially Inhibit Fibrin Formation in a Human Ex Vivo Thrombosis Model," Arterioscler. Thromb. Vasc. Biol. 15: 1098-1106.
Rose Eric
Schmidt Ann Marie
Spanier Talia
Stern David
O'Hara Kelly
The Trustees of Columbia University in the City of New York
White John P.
Yu Mickey
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