Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-06-05
1994-08-09
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 8, 530350, 536 235, 435 6, A61K 3700, A01N 3718, C07H 1700, C07K 300
Patent
active
053366670
ABSTRACT:
A family of proteins are provided which may be purified from snake venom. Each protein binds to the 45 kDa N-terminal domain of human platelet glycoprotein Ib, thereby inhibiting the binding of Von Willebrand factor to the domain. The proteins exist as multimers of individual polypeptide chains. The single polypeptide chains are useful for inhibiting the adhesion of platelets to subendothelial components of blood vessel walls exposed as the result of vascular damage.
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Kirby Edward P.
Peng Man-ling
Hill Jr. Robert J.
Temple University Of The Commonwealth System Of Higher Education
Wang Gian P.
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