Method for inhibiting sialidase activity

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

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514 25, 514 53, 536 172, 536 53, 53612313, C12N 924

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active

055124704

ABSTRACT:
Novel NeuAc-Gal dissacharide sialidase substrates and inhibitors which are locked into rigid conformation by the attachment of an alkyl group at the C-6 arm of the galactose core are provided. Also provided is a method for the inhibition of sialidase activity.

REFERENCES:
patent: 4375462 (1983-03-01), Berg et al.
patent: 5218097 (1993-06-01), Ernst
patent: 5318890 (1994-06-01), Rosen et al.
patent: 5330897 (1994-07-01), Pindak et al.
patent: 5438125 (1995-08-01), Okamoto et al.
Burnet, F. M. et al, Aust. J. Exp. Biol. Med. Sci., 25, 227-233 (1947).
Stone, J. D. , Aust. J. Exp. Biol. Med. Sci., 26, 48-64 (1948).
Pritchett, T. J. et al, Virology, 160(2), 502-506 (1987).
Pritchett, T. J. et al, J. of Biological Chemistry, 264(17), 9850-9858 (1989).
Air, G. M. et al, J. of Virology, 64(12), 5797-5803 (1990).
Nagai, T. et al, Chem. Pharm. Bull.,38(5), 1329-1332 (1990).
Suzuki, Y. et al, Glycoconjugate J, 7, 349-356 (1990).
Sabesan, S., Carbohydrate Research, 218, 27-54 (1991).
Hasegawa, A. et al, J. Carbohydrate Chem., 9(4), 369-392 (1990).
Sabesan, S. et al, Canadian Journal of Chemistry, 62(4), 644-654 (1984).
Sabesan, S. et al, J. Am. Chem. Soc., 108(8), 2068-2080 (1986).
Murase, T. et al, Chemical Abstracts, 112, Abstract No. 36327g (1990).
Weidmann, H. eta al, Chemical Abstracts, 86, Abstract No. 55643t, p. 461 (1977).
Jansson, K. et al, J. Org. Chem. , 53, 5629-5647 (1988).
Stout, E. I. et al, J. Org. Chem., 40(9), 1331-1336 (1975).
Cox, J. M. et al, J. Chem. Soc C, 1121-1130 (1967).
Daniel, J. R. et al,Carbohydrate Research, 64, 69-79 (1978).

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