Method for inhibiting pulmonary oxygen toxicity

Details Method for inhibiting pulmonary oxygen toxicity Method for inhibiting pulmonary oxygen toxicity

1993-02-10

1994-05-10

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

53038822, 53038873, 5303896, A61K 3900, A61K 39395, C07K 1528

Patent

active

053105516

ABSTRACT:
A method for inhibiting pulmonary oxygen toxicity in a patient requiring elevated levels of inhaled oxygen, by prophylactic administration of certain adhesion molecules and antibodies thereto.

REFERENCES:
patent: 5109123 (1992-04-01), Reinherz et al.
Barton et al., J. Immunol. 143:1278-1282 (1989) "The effect of anti-intercellular adhesion molecule-1 on phorbol-ester-induced rabbit lung inflammation".
Gallin, J. I. in Fundamental Immunology (W. F. Paul, (ed)) Ch. 26, pp. 721-733 (1989), "Inflammation".
Ruoslahti, et al. in Syn. Peptides in Biology and Medicine, pp. 191-197 (1985) "Synthetic peptides in analysis of cell adhesion".
Shevach, et al. in Fundamental Immunology (W. F. Paul (ed.)) Ch. 15, pp. 413-422, 437-438 (1989) "Accessory molecules".
Wegner et al., Science 247:456-459 (Jan. 20, 1990), "Intercellular adhesion molecule-1 (1 ICAM-1) in the pathogenesis of asthma".

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