Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-08-01
1996-04-02
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3147
Patent
active
055040934
ABSTRACT:
A method for inhibiting nucleoside and nucleobase transport in mammalian cells, as well as to a method for inhibition of DNA virus replication are disclosed, wherein each method uses, as the active agent, a carbostyril derivative.
REFERENCES:
patent: 4415572 (1983-11-01), Tominaga et al.
Sasayama et al, "Acute Hemodynamic Effects of a New Inotropic Agent, OPC-8212, On Severe Congestive Heart Failure", Heart and Vessels, 2(1):23-28 (1986).
Lueprasitsukul et al, "Effect of the Cardiac Inotropic Drug, OPC 8212, on Pituitary-Thyroid Function in the Rat, " Endocrinology, 128(6):2709-2714 (1991).
Berkow, Editor-in-Chief, "The Merck Manual of Diagnosis and Therapy", 15th Edition, Merck Sharp & Dohme Research Laboratories, Rahway, N.J., pp. 1043-1050 (1987).
Bush et al, "Effect of OPC-8212, A New Positive Intropic Agent, on the Hemopoietic System In Vitro", Experimental Hematology, 19(6):490 (1991).
Nakai et al, "Differentiation-Inducing Activity of 3,4-dihydro-6- 4-(3,4-dimethoxybenzoyl)-1-piperazinyl!-2(1H)-quinolinone (vesnarinone) Against Tumor Leukemia and Solid Tumor Cells, " Biomedicine & Pharmacotherapy, 46(5-7):308 (1992).
Miller, "Epstein-Barr Virus: Biology, Pathogenesis, and Medical Aspects", Virology, 2nd Edition, Chapter 68, pp. 1921-1958 (1990).
Matsumori et al, "Vesnarinone, a New Inotropic Agent, Inhibits Cytokine Production by Stimulated Human Blood From Patients With Heart Failure", Circulation, 89(3):955-958 (1994).
Shioi et al, "Inhibition of Cytokine Production by a New Inotropic Agent, Vesnarinone, In Human Lymphocytes, T Cell Line, and Monocytic Cell line", Life Sciences, 54:11-16 (1994).
Meyerhans et al, "Restriction and Enhancement of Human Immunodeficiency Virus Type 1 Replication by Modulation of Intracellular Deoxynucleoside Triphosphate Pools", J. Virol., 68(1):535-540 (1994).
O'Brien et al, "Kinetics of Human Immunodeficiency Virus Type 1 Reverse Transcription in Blood Mononuclear Phagocytes are Slowed by Limitations of Nucleotide Precursors", J. Virol., 68(2):1258-1263 (1994).
Gao et al, "Low levels of Deoxynucleotides in Peripheral Blood Lymphocytes: A Strategy to Inhibit Human Immunodeficiency Virus Type 1 Replication", Proc. Natl. Acad. Sci. USA 90:8925-8928 (1993).
Maruyama et al, "Vesnarinone Inhibits Production of HIV-1 in Cultured Cells", Biochemical and Biophysical Research Communications, 195(3):1264-1271 (1993).
Datta et al, "Acyclovir Inhibition of Epstein-Barr Virus Replication", Proc. Natl. Acad. Sci. USA 77(9):5163-5166 (1980).
Gelfand Erwin W.
Terada Naohiro
Carr Deborah D.
Dees Jos,e G.
Otsuka Pharmaceutical Co. Ltd.
LandOfFree
Method for inhibiting nucleoside and nucleobase transport in mam does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for inhibiting nucleoside and nucleobase transport in mam, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting nucleoside and nucleobase transport in mam will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2016490