Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1993-12-02
1996-06-25
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514173, A61K 3171
Patent
active
055299920
ABSTRACT:
This invention discloses a method of using an aldosterone antagonist such as spironolactone, at a dosage which does not disrupt a patient's normal electrolyte and water-retention balance, to inhibit myocardial fibrosis, including left ventricular hypertrophy (LVH).
REFERENCES:
patent: 4003996 (1977-01-01), Pappo et al.
Remington's Pharmaceutical Sciences, 15th edition 1975, pp. 867-868.
Doering, C. W., et al, "Collagen network remodeling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy," Cardiovasc. Res. 22: 686-695 (1988).
Brilla, C. G., et al, "Remodeling of the rat right and left ventricle in experimental hypertension," Circ. Res. 67: 1355-1364 (1990).
Weber, K. T., et al, "Structural remodeling of myocardial collagen in systemic hypertension: functional consequences and potential therapy," Heart Failure 6: 129-137 (1990).
Weber, K. T., et al, "Myocardial remodeling and pathologic hypertrophy," Hospital Practice 26(4): 73-80 (1991).
Andreoli, T. E., "Introduction: Modern aspects of congestive heart failure," Hospital Practice 26(4): 7-8 (1991).
Brilla, C. G., et al, abstract, "Myocardial fibrosis in experimental hypertension: potential role of fibroblast corticoid receptors," J. Hypertension 8: S8 (1990).
Weber, K. T., and Brilla, C. G., "Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensin-aldosterone system," Circulation 83: 1849-1865 (Jun. 1991).
Weber, K. T., and Brilla, C. G., "Myocardinal fibrosis and elevations in plasma aldosterone in arterial hypertension," Aldosterone: Fundmental Aspects 215: 117-120 (1991).
Brilla, C. G., and Weber, K. T., "Prevention of myocardial fibrosis in hypertension: role of fibroblast corticoid receptors and spironolactone" Proceedings of the 75th Annual Meeting of the Fed. of Amer. Societies for Exper. Biology, 1991, abstract No. A1256, published Apr. 21, 1991.
American Journal of Cardiology, Klug et al., "Role of Mechanical and Hormonal Factors in Cardiac Remodeling and the Biologic Limits of Myocardial Adaptation," Jan. 21, 1993, vol. 71, No. 3, pp. 46A-54A.
Journal of Molecular and Cellular Cardiology, Brilla et al., "Anti-Aldosterone Treatment and the Prevention of Myocardial Fibrosis in Primary and Secondary Hyperaldosteronism," May 1993, vol. 25, No. 5, pp. 563-575.
American Journal of Cardiology, Brilla et al., "Antifibrotic Effects of Spironolactone in Preventing Myocardial Fibrosis in Systemic Arterial Hypertension," Jan. 21, 1993, vol. 71, No. 3, pp. 12A-16A.
Journal of Pharmacology and Experimental Therapeutics, "Three New Epoxy-Spirolactone Derivatives: Characterization in vivo and in vitro,"Feb. 1987, vol. 240, No. 2, pp. 650-656.
Bundesverbrand D. Pharm. Ind. E. V., "Rote Liste," 1987 Editio Cantor, Aulendorf/Wortt.
Cook Rebecca
Curators of the University of Missouri
LandOfFree
Method for inhibiting myocardial fibrosis by administering an al does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for inhibiting myocardial fibrosis by administering an al, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting myocardial fibrosis by administering an al will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2188934