Method for inhibiting mineralization of natural tissue during im

Details Method for inhibiting mineralization of natural tissue during im Method for inhibiting mineralization of natural tissue during im

1981-04-30

1982-04-06

Tungol, Maria Parrish

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

3 14, 3 15, A61F 122

Patent

active

043233589

ABSTRACT:
Natural tissues fixed with a tanning solution such as glutaraldehyde and intended for implantation in humans, e.g., porcine heart valve prosthetic devices, are treated with a solution of a water soluble salt of a sulfated higher aliphatic alcohol such as sodium dodecyl sulfate to inhibit mineralization, particularly calcification, of the tissue after implantation.

REFERENCES:
patent: 3966401 (1976-06-01), Hancock et al.
patent: 4050893 (1977-09-01), Hancock et al.
Miller, Zelma B., et al.: "The Effect of Dyes on the Calcification of Hypertrophic Rachitic Cartilage In Vitro", J. Exp. Med. 95, 497-508 (1952).
Sobel, Albert Edward et al.: "Calcification XIV. Investigation of the Role of Chondroitin Sulfate in the Calcifying Mechanism", Proc. Soc. Exp. Biol. Med. 87, 7-13 (1954).
Urist, Marshall R., et al.: "Effects of Various Blocking Reagents Upon Local Mechanism of Calcification", Arch. Pathol. 81, 325-342 (1966).

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