Method for inhibiting immune response

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai

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A61K 3128

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active

057080224

ABSTRACT:
Use of ruthenium complexes as immunosuppressive agents to prevent or significantly reduce graft rejection in organ and bone marrow transplantation is described. The ruthenium complexes can also be used as immunosuppressant drugs for T-lymphocyte mediated autoimmune diseases, such as diabetes, and may be useful in alleviating psoriasis and contact dermatitis. The ruthenium complexes can also be used therapeutically in the treatment of hyperproliferative vascular disease.

REFERENCES:
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patent: 5238689 (1993-08-01), Dwyer et al.
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Heijden et al., "Synthesis and Characterization of cis-(2,2'-Bipyridine) (2, 2'-biquinoline)dichlororuthenium (II) and its Co-ordination Chemistry with Imidazole Derivatives", J. Chem. Soc. Dalton Trans., 24:3675-9 (1993).
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Anghileri, L., "The in vivo Inhibition of Tumor Growth by Ruthenium Red: Its Relationship with the Metabolism of Calcium in the Tumor", Z. Krebsforsch, 83:213-217 (1975).
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