Method for inhibiting IgE production

Details Method for inhibiting IgE production Method for inhibiting IgE production

1990-12-27

1992-10-20

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560121, 562503, C07C17700, A61K 31557

Patent

active

051570521

ABSTRACT:
A method is described for inhibiting IgE production which comprises administering, in an amount effective to inhibit IgE production, a prostaglandin of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, in which R is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, or mono, di- or tri-substituted phenyl in which the substituents, are selected from the group consisting of bromo, chloro, fluoro, iodo, C.sub.1 -C.sub.5 alkyl, hydroxy, nitro, acetyl, alkoxy, carboxy, acetoxy, amino, mono- or di- alkyl amino, amido and acetamido; R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.5 alkyl, n.sub.3, n.sub.4, n.sub.5, n.sub.6, n.sub.7, and n.sub.8 independently are zero or one; when n's are zeros, R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, R.sub.5 and R.sub.6 together, and R.sub.7 and R.sub.8 together are double bonds; when n's are ones, R.sub.3, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 independently are hydrogen, R.sub.4 is hydrogen or methyl, or R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, or R.sub.5 and R.sub.6 together are methylene.

REFERENCES:
patent: 3965143 (1976-06-01), Collins
patent: 4332543 (1982-03-01), Collins
Goodwin, Prostaglandins 33 (Suppl.) 61-7 (1987).
Reimann, Prostaglandins 33 (Suppl.) 105-118 (1987).

Affiliated with

Also associated with

Rating

Method for inhibiting IgE production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for inhibiting IgE production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting IgE production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-192438