Method for inhibiting heparanase activity

Details Method for inhibiting heparanase activity Method for inhibiting heparanase activity

1990-09-17

1993-04-27

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514825, 514885, 536 21, A61K 31725, C08B 3710

Patent

active

052062236

ABSTRACT:
Heparanase activity in a patient may be inhibited by administering an effective heparanase-inhibiting amount of heparin or an effective chemically modified derivative of heparin which inhibits heparanase activity. Such derivatives are preferably N-desulfated, N-acetylated heparin or O-desulfated, N-acetylated heparin. By means of this invention, allograft rejection may be prevented or delayed and autoimmune diseases such as arthritis may be alleviated and treated.

REFERENCES:
patent: 3033750 (1962-05-01), Velluz et al.
patent: 3062716 (1962-11-01), Montandraud
patent: 3636202 (1972-01-01), Klein
patent: 4882318 (1989-11-01), Vlodavsky et al.
patent: 4889808 (1989-12-01), Rappaport
Folkman et al., Science, vol. 221, 19 Aug. 1983, pp. 719-725.
MacDonald, Chem. Abstracts, vol. 72:76999g (1970).

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