Method for inhibiting growth of helicobacter pylori

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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514699, 514926, 514927, A61K 3578, A61K 3111

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active

055609120

ABSTRACT:
The invention relates to the use of an organic extract of the plant Cinnamon or a chemical constituent present in said plant, to prepare a pharmaceutical composition useful to inhibit the growth of Helicobacter pylori and the urease activity of Helicobacter pylori. Most preferred chemical constituents are cinnamaldehyde and methoxycinnamaldehyde. The extract may be used either as a drink, with or without additional flavoring ingredients or transformed into a capsule. The invention also relates to in-vitro method for determininig the inhibition of urease activity of Helicobacter pylori using said organic extract of the plant or chemical constituents present in said plant.

REFERENCES:
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Andrew H. Soll, "Pathogenesis Of Peptic Ulcer And Implications For Therapy". The New England Journal Of Medicine, Mar. 29, 1990, pp. 909-916.
Gabriele Geis et al., "Unusual Fatty Acid Substitution in Lipids and Lipopolysaccharides of Helicobacter pylori", Journal of Microbiology, May 1990, pp. 930-932.
K. Rosberg et al., "Adhesion of Helicobacter pylori to Human Gastric Mucosal Biopsy Specimens Cultivated in Vitro", Scand. J. Gastroenterol 1991, 26, pp. 1179-1187.
H. G. Desai et al., "Dental Plaque: A Permanent Reservoir of Helicobacter pylori?", Scand. J. Gastroenterol 1991, 26, pp. 1205-1208.
Laura L. Zaika, "Spices and Herbs: Their Antimicrobial Activity and Its Determination", Journal of Food Safety 9, 1988, pp. 97-118.
E. F. Steinmetz, Cotex Vegetabilis 1957.

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