Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Reexamination Certificate
2000-03-30
2001-07-03
Pak, John (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
C514S724000, C514S763000, C514S919000, C424SDIG001
Reexamination Certificate
active
06255356
ABSTRACT:
BACKGROUND OF THE INVENTION
My invention relates to methods of inhibiting from feeding the German cockroach (
Blattella germanica
) from a surface or volume inhabited by such insect species using as an anti-feedant composition materials known as “GERANIOL COEUR™” (trademark of International Flavors & Fragrances Inc.) defined according to the GLC profiles of
FIGS. 4 and 5
and produced according to Examples, I and II, infra (also set forth herein as “geraniol-containing or geraniol-containing mixtures”).
The “GERANIOL COEUR™” used in my invention comprises:
(i) from about 0 up to about 20% by weight of nerol;
(ii) from about 20 up to about 40% by weight of citronellol; and
(iii) from about 50 up to about 70% by weight of geraniol.
The GERANIOL COEUR™ used as an anti-feedant against such insect species can either be natural GERANIOL COEUR™ or synthetic GERANIOL COEUR™. Such GERANIOL COEUR™ compositions of matter contain a large number of additional chemicals, a number of which may be active in combination with the major components of the GERANIOL COEUR™, namely, the nerol, citronellol and geraniol and trace amounts of other materials.
The German cockroach (
Blattella germanica
) is known to cause health problems among various mammalian species and is a well known insect pest. Accordingly, a need exists for inhibiting from feeding such insect species, the German cockroach (
Blattella germanica
), from surfaces or volumes which are inhabited by such species and which are proximate the living space of mammalian species such as
Homo sapiens.
GERANIOL COEUR™, both synthetic and natural, is described for use in repelling fire ants and horn flies in U.S. Pat. No. 5,753,686 issued on May 19, 1998, the specification for which is incorporated herein by reference. Described in said U.S. Pat. No. 5,753,686 is a method for repelling at least one of the insect species:
(i)
Haematobia irritans
(Linnaeus) (commonly known as the horn fly); and
(ii)
Solenopsis invicta
Buren (commonly known as the “red imported fire ant”)
from a surface or volume inhabited by at least one of said insect species consisting of the step of applying to said surface or said volume a “red imported fire ant” and/or horn fly-repelling quantity and concentration of a geraniol-containing mixture comprising:
(i) from about 0 up to about 20% by weight of nerol;
(ii) from about 20 up to about 40% by weight of citronellol; and
(iii) from about 50 up to about 70% by weight of geraniol,
which geraniol-containing mixture is defined according to specific GLC profiles, to wit, those set forth in
FIGS. 4 and 5
of the instant specification.
Citronellol (both the “d” isomer and the “I” isomer) are described as weak repellents for the yellow-fever mosquito and
Aedes aegypti
in CHEMICALS EVALUATED AS INSECTICIDES AND REPELLENTS AT ORLANDO, FLA., King, U.S. Department of Agriculture, Agricultural Research, Agriculture Handbook No. 69, at page 120 (Items 3441 and 3442) (published May 1954).
“Geraniol” and various fractions of Java Citronella oil also described as “geraniol” are stated in the King reference at page 179 to be yellow-fever repellents and repellents for
Aëdes aegypti
. Reference is made to Items 5366 (“geraniol”); 5371 (“geraniol, first fraction of Java Citronella oil”); 5372 (“geraniol, second fraction of Java Citronella oil”); 5373 (“geraniol, last fraction of Java Citronella oil”); and 5374 (“geraniol, last fraction, high boiling, Java Citronella oil”).
On the other hand, Beroza and Green, MATERIALS TESTED AS INSECT ATTRACTANTS, Agriculture Handbook No. 239, Agricultural Research Service, United States Department of Agriculture, June 1963, discloses 3,7-dimethyl octanol-1 having the strucuture:
(Item 2883) as being an attractant for the oriental fruit fly, the melon fly and the Mediterranean fruit fly at a level of “1” on a scale of “1-3”. The Beroza and Green reference also describes isomers of citronellol and geraniol as having attractancy for various insect species including the pink bollworm and the boll weevil. Thus, Items 2894, 2895 and 2875 for compounds having the structures:
are shown by Beroza and Green to have weak attractancies for the oriental fruit fly, the melon fly, the Mediterranean fruit fly, the Mexican fruit fly, the gypsy moth, drosophila, the peak bollworm and the boll weevil at levels of “1” or “2” on a scale of “1-3”.
Nothing in the prior art, however, teaches the inhibition from feeding against the German cockroach (
Blattella germanica
) of GERANIOL COEUR™ either natural or synthetic, and nothing in the prior art infers such anti-feedant properties.
THE INVENTION
My invention is directed to a method for inhibiting from feeding the German cockroach (
Blattella germanica
) from a surface or volume inhabited by the German cockroach (
Blattella germanica
) insect species consisting of the step of applying to said surface or said volume a German cockroach (
Blattella germanica
)-anti-feedant quantity and concentration of a geraniol-containing composition, GERANIOL COEUR™, natural (shown to be produced in Example I, infra) or synthetic (shown to be produced according to Example II, infra) comprising:
(i) from about 0 up to about 20% by weight of nerol;
(ii) from about 20 up to about 40% by weight of citronellol; and
(iii) from about 50 up to about 70% by weight of geraniol
defined according to the GLC (gas liquid chromatography) profiles of
FIGS. 4 and 5
described, infra. Such GERANIOL COEUR™ has a refractive index in the range of from about 1.45 up to about 1.48 and a density in the range of from about 0.85 up to about 0.88 at a temperature in the range of from about 20° C. up to about 25° C.
My invention is also directed to anti-feedant compositions containing such GERANIOL COEUR™, which compositions inhibit the feeding by said German cockroach (
Blattella germanica
). Accordingly, my invention is directed to a process for inhibiting feeding by the German cockroach (
Blattella germanica
) using the GERANIOL COEUR™ defined, supra.
The GERANIOL COEUR™ natural and GERANIOL COEUR™ synthetic compositions are similar but each has other chemical constituents in addition to the nerol, citronellol and geraniol and these constituents vary from the synthetic to the natural citronellol and geraniol and these constituents vary from the synthetic to the natural GERANIOL COEUR™. The additional constituents, for example, in the GERANIOL COEUR™, include but are not limited to 3,7-dimethyl octanol-1 having the structure:
(found primarily in the synthetic GERANIOL COEUR™) and &bgr;-elemene having the structure:
found in the natural GERANIOL COEUR™. The natural GERANIOL COEUR™'s GLC spectrum is set forth in FIG.
4
and synthetic GERANIOL COEUR™'s GLC spectrum is set forth in FIG.
5
.
When discussing a “surface” inhabited by the
Blattella germanica
, such surface can be the skin of an animal such as a cow or the skin of a human being. When discussing the term “volume” inhabited by the
Blattella germanica
, such a volume would be an air space a human being, for example, or the volume could be a room into which a person will enter.
The coating of the GERANIOL COEUR™ onto the skin can be in several forms:
(i) in the form of an aerosol wherein the GERANIOL COEUR™ is incorporated into a standard aerosol formulation at the level of 0.05% up to about 5%; and
(ii) in a non-toxic polymer such as polyvinyl alcohol or polyethylene or polypropylene at the levels of from about 1.0% of GERANIOL COEUR™ up to about 45% by weight of the polymer mixture of GERANIOL COEUR™.
Thus, my invention also contemplates anti-feedant formulations containing a base and incorporated into said base an anti-feedant quantity or concentration of GERANIOL COEUR™, the geraniol-containing mixture, defined according to the GLC spectra of
FIGS. 4
or
5
as more specifically described, infra.
The term “citronellol” includes &agr;-citronellol having the structure:
in both its “d” and “l” forms and &bgr;-citronellol having the structure:
in both its “d” and “l” forms. GERANIOL COEUR™ natural and GERANIOL COEUR™ synthetic contain,
International Flavors & Fragrances Inc.
Leightner Joseph F.
Pak John
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