Method for inhibiting emesis and compositions therefor

Details Method for inhibiting emesis and compositions therefor Method for inhibiting emesis and compositions therefor

1973-05-03

1978-07-18

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

A61K 31445

Patent

active

041016629

ABSTRACT:
1,4-(3-)Disubstituted piperidines are disclosed which have useful antiemetic properties. The compounds have the general formula: ##STR1## wherein R is halogen, R.sup.1 is hydrogen and halogen, n is a positive integer from 2-4 and A is --C(O)-- and --CHOH--. The pharmaceutically acceptable acid addition salts of the basic compounds are particularly useful as antiemetics.

REFERENCES:
patent: 3128278 (1964-04-01), Craig et al.
patent: 3576810 (1971-04-01), Duncan et al.
patent: 3852455 (1974-12-01), Carr
Martin et al., Remington Practice of Pharmacy, 12th Ed., pp. 1052-1059, (1976), Mack Pub. Co., Easton, Pa.

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