Method for inhibiting cytokine secretion

Details Method for inhibiting cytokine secretion Method for inhibiting cytokine secretion

1995-09-05

2000-03-07

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514255, A61K 3147, A61K 31495

Patent

active

060341009

ABSTRACT:
A method for the prophylaxis and treatment of diseases induced by acceleration of secretion of cytokines (e.g. TNF-.alpha., IL-1, IL-6, IL-8, and IFN-.gamma.) which comprises administering a benzoheterocyclic compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and X.sup.1 is halogen, R.sup.3 is lower alkyl, R.sup.4 is hydroxy, and X.sup.2 is halogen, or a pharmaceutically acceptable salt thereof.

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J. Infect. Dis., 1985, 152 (4), pp. 811-816.
Antimicrob. Agents Chemother. 1986, 30 (1), pp. 184-186.

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