Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1995-10-19
1997-09-23
Weber, Jon P.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435267, 435268, 435381, 435378, C12N 948, C07G 1700, C07G 1500
Patent
active
056703589
ABSTRACT:
The activities of chymopapain or papain in enzyme mixtures are inhibited by the addition of glycogen, hyaluronic acid, or desulfated heparin. The process for isolating viable hepatocytes or pancreatic cells by treatment with papain or chymopapain is improved by terminating the treatment by inhibiting the reaction with these polysaccharides. Similarly, the process for removing undesired tissue by treatment with papain or chymopapain is improved by terminating the treatment by inhibiting the reaction with these polysaccharides.
REFERENCES:
patent: 3558433 (1971-01-01), Stern
patent: 4142999 (1979-03-01), Blocking et al.
patent: 4167447 (1979-09-01), Masuri et al.
patent: 4212945 (1980-07-01), Nonaka et al.
patent: 4212946 (1980-07-01), Nonaka et al.
patent: 4374926 (1983-02-01), Stern
patent: 4439423 (1984-03-01), Smith
patent: 4439521 (1984-03-01), Archer et al.
patent: 4652525 (1987-03-01), Rutter et al.
patent: 4696816 (1987-09-01), Brown
patent: 4719108 (1988-01-01), Smith
patent: 4797213 (1989-01-01), Parisius et al.
patent: 4812314 (1989-03-01), Barenholz et al.
patent: 4868121 (1989-09-01), Scharp et al.
patent: 4935000 (1990-06-01), Dudek
patent: 4978332 (1990-12-01), Luck et al.
patent: 5079160 (1992-01-01), Lacy et al.
patent: 5112757 (1992-05-01), Guguen-Guillouzo et al.
patent: 5116615 (1992-05-01), Gokcen et al.
patent: 5177017 (1993-01-01), Lin et al.
patent: 5227157 (1993-07-01), McGinty et al.
patent: 5424208 (1995-06-01), Lee et al.
Journal of Supramolecular Structure, vol. 14, No. 1, 1980, pp. 33-46, Victor B. Hatcher, et al: "Inhibition of Cell Proliferation and Protease Activity By Cartilage Factors and Heparin".
Tanaka, H., et al: "Effects of SL-1010 (Sodium Hyaluronated With High Molecular Weight) on Experimental Osteoarthritis Induced By Intra-Articularly Applied Papain in Guinea Pigs". Nippon Yakurigaku Zasshi, vol. 100, No. 1, pp. 77-86, Abstract in Medicine AN 92355006.
Kitoh, Y., et al: "Effects of Sl-1010 (Sodium Hyaluronated With High Molecular Weight) On Experimental Osteoarthritis Induced By Intra-Articularly Applied Papain In Rabbits,"Nippon Yakurigaku Zasshi, 100(1), pp.67-76, Abstract in Medicine, AN 92355005.
Valeri et al.(1980) Biochim. Biphys. Acta, 614(2), "Reaction of Antithrombin with Proteases Evidence for a Specific Reaction with Papain", pp. 526-533.
Alberts et al. (1983) "Molecular Biology of the Cell", Garland Publishing, Inc., New York, pp. 702-707.
C.C. Worthington, Worthington Enzyme Manual, "Enzymes and related biochemicals", pp. 93-95, Worthington Biochemical Corp.
M.Maeda, Okayama Igakkai Zasshi, 1986, "Studies on the characteristics of human lung mast cell", pp. 475-486.
I.Maruyama et al, Journal of Pharmacol. Methods, pp. 151-161, 1987, "Preparation of Single Smooth Muscel Cells from Guinea Pig Taenia Coli by . . . Collagenase and Papain".
B.J. Bolzon & D.W. Cheung, Hypertension, vol. 14, Aug. 1989, pp. 137-144, "Isolation & Characterization of Single Vasacular Smooth Muscle Cells . . .".
I.Maruyama et al., Journal Pharmacol. Methods, 1988, pp. 155-164, "Improvement of a Procedure for Preparing Single Smooth Muscel Cells from Guinea Pig Tenia Coli Collagenase and Papin".
E. Lammel et al, Journal of Physicolgy, 1991, pp.259-282, "Suppression of Steady Membrane Currents by Acetylcholine in Single Smooth Muscel Cells of the Guinea Pig Gastric Fundus".
K. Tavakol, Surgical Forum USA, vol. XXXVII, pp. 491-494, "Enhanced Dissolution of Nucleus Pulposus: Combined Enzyme Approach".
Kazutaka Momose, Pharmacologica, vol. 101, No. 3, Mar. 1993, "Isolation, configuration and contractile responses o single smooth muscle cells".
Dinh Tan Thanh
Lee Catherine T.
Ma Minh T.
Zerfass Cynthia
Baxter International Inc.
Weber Jon P.
LandOfFree
Method for inhibiting chymopapain and papain enzyme activity wit does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for inhibiting chymopapain and papain enzyme activity wit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting chymopapain and papain enzyme activity wit will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1938330