Method for inhibiting cellular proliferation using antisense oli

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 245, C12N 506, C07H 2100

Patent

active

057168466

ABSTRACT:
The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.

REFERENCES:
patent: 5225326 (1993-07-01), Bresser et al.
patent: 5252723 (1993-10-01), Bhatt
patent: 5470824 (1995-11-01), Miles et al.
patent: 5489519 (1996-02-01), Deeley et al.
patent: 5585479 (1996-12-01), Hoke et al.
Gura "Antisense has growing pains" Science 270: 575-577, Oct. 1995.
Keller et al. "Effect of IL-6 receptor antisnese oligodeoxynucleotide on in vitro proliferation of myeloma cells" J. Immunol. 154: 4091-4098, Apr. 1995.
Milligan et al "Current concepts in Antisense drug design" J. Med. Chem. 36: 1923-1937, Jul. 1993.
Zon et al. "Phosphorothioate oligonucleotides" in Oligonucleotides and analogues, Eckstein, ed. IRL Press, pp. 87-108, 1991.
Gewirtz et al. "Facilitating oligonucleotide delivery: Helping antisense deliver o its promise" Proc. Natl. Acad. Sci. USA 93: 3161-3163, Apr. 1996.
Plenat "Animal models of antisense oligonucleotides: lessons for use in humans" Mol. Med. Today 2(6): 250-257, Jun. 1996.
Rojanasakul "Antisense oligonucleotide therapeutics: drug delivery and targeting" Adv. Drug Design Rev. 18: 115-131, 1996.
Stull et al. "Antigene, ribozyme, and aptamer nucleic acid drugs: Progress and prospects" Parm. Res. 12(4): 465-483, Apr. 1995.
D'Hellencourt, et al., "Immunomodulation by cytokine antisense oligonucleotides", European Cytokine Network, 6(1):7-19, (1995).
Keller, et al., "Effect of IL-6 receptor antisense oligodeoxynucleotide on in vitro proliferation of myeloma cells", J. Immunol., 154(8):4091-4098, (1995).
Reddy, et al., "Interleukin-6 antisense deoxynucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone", J. Bone Miner. Res., 9(5):753-757, (1994).
Miller, et al., "Gene Transfer and Antisense Nucleic Acid Techniques", Parasitiology Today, 10(3):92-97, (Mar. 1994).
Stein, et al., "Antisense Oligonucleotides as Therapeutic Agents--Is the Bullet Really Magical", Science, 261:1004-1012, (Aug. 20, 1993).
Wu-Pong, S., "Oligonucleotides: Opportunities for Drug Therapy and Research", Pharmaceutical Technology, 18:102-104, (Oct. 1994).
Wagner, R., "Gene inhibition using antisense oligodeoxynucleotides", Nature, 372:333-335, (Nov. 1994).
Weiss, R., "Upping the Antisense Ante", Science News, 139:108-109, (Feb. 16, 1991).
Bennett, F., "Antisense Research", Science, 271:434, (Jan. 26, 1996).
Uhlmann, et al., "Antisense Oligonucleotides: A New Therapeutic Principle", Chemical Reviews, 90(4):543-584, (Jun. 1990).
Bangham, et al. Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Med. Biol. 13:238-252 (1965).
Caruthers, et al. Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method. Methods in Enzymology 154:287-313 Academic Press Inc. (1987).
Girasole, et al. Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. The Journal of Clinical Investigation, Inc., 89:883-891 (1992).
Grossman, et al. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl. Acad. Sci. 86:6367-6371 Medical Sciences (1989).
Hibi, et al. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149-1157 Cell Press (1990).
Jilka, et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-91 (1992).
Klein, et al. Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma. Eur. Cytokine Net., 1:193-201 (1990).
Levy, et al. Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines. J. Clin. Invest. 88:696-699 The American Society for Clinical Investigation, Inc. (1991).
Majumdar, et al. Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide. Biochemistry 28:1340-1346 American Chemical Society (1989).
Milligan, et al. Development of antisense therapeutics. Implications for cancer gene therapy. Annals New York Academy of Sciences 716:228-241 (1994).
Scala, et al. Expression of an exogenous interleukin 6 gene in human epstein barr virus B cells confers growth advantage and in vivo tumorigencity. J. Exp. Med. 172:61-68 The Rockefeller University Press (1990).
Shuin, et al. The activity of topoisomerases is related to the grade and stage in.
Stec, et al., Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogues of oligodeoxyribonucleotides. J. Am. Chem. Soc. 106:6077-6079 American Chemical Society (1984).
Stein, et al. Phosphorothioate oligodeoxynucleotides-anti-sense inhibitors of gene expression. Pharmac. Ther. 52:365-384 Pergamon Press Ltd. Great Britian (1992).
Taga, et al. Receptors for B cell stimulatory factor 2 quantiation, specificity, distribution, and regulation of their expression. J. Exp. Med. 166:967-981 The Rockefeller University Press (1987).
Taga, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58:573-581 Cell Press (1989).
Takenawa, et al. Enhanced expression of interleukin-6 in primary human renal cell carcinomas. Journal of the National Center Institute 83:1668-1672 (1991).
Vink, et al. Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against Il-6 or its receptor. J. Exp. Med. 172:997-1000 The Rockefeller University Press (1990).
Ward, et al. High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. The Journal of Biological Chemistry 269:23286-23289 The American Society for Biochemistry and Molecular Biology, Inc. U.S.A. (1994).
Yamasaki, et al. Cloning and expression of the human interleukin-6 (BSF-2/IFNB 2 ) receptor. Science 241:825-828 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for inhibiting cellular proliferation using antisense oli does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for inhibiting cellular proliferation using antisense oli, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting cellular proliferation using antisense oli will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2076587

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.