Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1997-12-02
1999-12-28
Nutter, Nathan M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
8 9411, 623 11, A61L 2700
Patent
active
060082925
ABSTRACT:
A method for preparing collagenous biological tissues for use as implantable bioprosthetic material, and articles prepared thereby. The method generally comprises the steps of a) contacting the tissue with an aldehyde fixative to effect cross-linking of the connective tissue protein(s) and subsequently b) contacting the tissue with a polyglycidyl ether. The treatment of the crosslinked tissue with the polyglycidyl ether serves to mitigate the tissue's propensity to undergo calcification following implantation in the body.
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Chachra et al., "Effect of Applied Uniaxial Stress on Rate and Mechanical Effects of Cross-Linking in Tissue-Derived Biomaterials, " Biomaterialsvol. 17, Oct 1996, 1865-1875.
Zhou et al., "Porcine Aortic Wall Flexibility Fresh vs Denacol Fixed vs Glutaraldehyde Fixed," ASIAO Journal, vol. 43, No. 5, 470-475, Sep 1997, Edwards CVS Division, Baxter Healthcare Corporation.
Dinh Tan Thanh
Lee Catherine Ting
Pfadenhauer Ernest H.
Yang Jun
Baxter International Inc.
Buyan Robert D.
Cumberbatch Guy L.
Nutter Nathan M.
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