Method for inhibiting blood vessel blockage using octapeptide co

Details Method for inhibiting blood vessel blockage using octapeptide co Method for inhibiting blood vessel blockage using octapeptide co

1989-03-28

1992-09-15

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 514 12, 530311, C07K 726

Patent

active

051478560

ABSTRACT:
A method for inhibiting blood vessel blockage in a mammal particularly after a procedure such as angioplasty, an arterial bypass operation or an allograft transplant operation which comprises: administering to a mammal before, during and/or after the procedure an effective blood vessel blockage inhibiting amount of an octapeptide having the formula ##STR1## wherein each A.sub.1 and A.sub.2, independently, is H, C.sub.1-12 alkyl, C.sub.7-10 phenylalkyl, R.sub.1 CO (where R.sub.1 is C.sub.1-20 alkyl, C.sub.3-20 alkenyl, C.sub.3-20 alkinyl, phenyl, naphthyl, or C.sub.7-10 phenylalkyl), or R.sub.2 OCO (where R.sub.2 is C.sub.1-10 alkyl or C.sub.7-10 phenylalkyl), provided that when one of A.sub.1 or A.sub.2 is R.sub.1 CO or R.sub.2 OCO, the other must be H; A.sub.3 is CH.sub.2 A.sub.6 (where A.sub.6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A.sub.4 is o-, m- or, more preferably, p-substituted X-Phe (where X is a halogen, H, NH.sub.2, NO.sub.2, OH , or C.sub.1-13 alkyl), pentafluoro-Phe, or .beta.-Nal; A.sub.5 is Thr, Ser, Phe, Val, .alpha.-aminobutyric acid, or Ile; A.sub.7 is Thr, Trp, or .beta.-Nal (and can be either the D- or L-isomer); and Z is NH.sub.2 or OH; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4485101 (1984-11-01), Coy et al.
patent: 4663309 (1987-05-01), Kaiser et al.
patent: 4853371 (1989-08-01), Coy et al.

Affiliated with

Also associated with

Rating

Method for inhibiting blood vessel blockage using octapeptide co does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for inhibiting blood vessel blockage using octapeptide co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting blood vessel blockage using octapeptide co will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-736698