Method for inhibiting bacterial growth in a leuko-reduced...

Details Method for inhibiting bacterial growth in a leuko-reduced... Method for inhibiting bacterial growth in a leuko-reduced...

2004-01-14

2010-10-19

Saucier, Sandra E (Department: 1651)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

Reexamination Certificate

active

07816073

ABSTRACT:
Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.

REFERENCES:
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patent: 6482585 (2002-11-01), Dottori
patent: 6960428 (2005-11-01), Dottori
Ogawa et al., “Clinical evaluation of transfusion of prestorage-leukoreduced apheresis platelets”, Vox Sanguinis 75 (2) : 103-9 (1998).
Tegos et al., “Platelet glycolysis in platelet storage”, Transfusion 19 (2) : 203-5 (1979).
Sweeney, et al., “L-Carnitine and L-Acetylcarnitine May Reduce Glycolysis in Stored Platelet Concentrates”, Vox Sanguinis, (Jun. 1998), 74, (1): 1226, 25thCongress of the International Society of Blood Transfusion, Oslo, Norway, Jun. 27-Jul. 2, 1998.
A. Arduini, et al., Addition of L-Carnitine to Additive Solution-Suspended Red Cells Stored At 4 Degrees Reduces in Vitro Hemolysis and Improves in Vivo Viability, Transfusion, Feb. 1997, 37 (2), pp. 166-74 (Abstract Only).

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