Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1995-06-07
1998-02-24
Prior, Kimberly J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514170, 514171, 514172, 514173, 514174, 514175, 514176, 514177, 514178, 514179, 514180, 514181, 514182, A61K 3156, A61K 3157, A61K 3158, A61K 31575
Patent
active
057212260
ABSTRACT:
A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a compound according to the following Formula (III) (or a pharmaceutically acceptable salt thereof) can be administered: ##STR1## wherein Z.sub.5 is .alpha.-H or .beta.-H; each of the substituents Z.sub.7 is selected from the group of --H, --OH, --SH, --NH.sub.2, --F, --(C.sub.1 -C.sub.3)-alkyl, and --(C.sub.1 -C.sub.3)-alkoxy; and one of the substituents Z.sub.12 is --H and the other is --H or --OH. X' is a polyamine side chain of the formula --X.sub.1 --(CH.sub.2).sub.p --X.sub.2 --(CH.sub.2).sub.q --N(R.sup.II)(R.sup.III), wherein one of X.sub.1 and X.sub.2 is --N(R.sup.IV) and the other is selected from the group of --N(R.sup.V), --O, --S, and --CH.sub.2. R.sup.IV and R.sup.V are each --H or --(C.sub.1 -C.sub.3)-alkyl, p and q are each an integer of from 0 to 5 (but both are not 0). R.sup.II and R.sup.III in the formula for X' are each --H, --(C.sub.1 -C.sub.3)-alkyl, or --(CH.sub.2).sub.r --N(R.sub.10)(R.sub.11) wherein r is an integer from 2 to 5 and R.sub.10 and R.sub.11 are each --H or --(C.sub.1 -C.sub.3)-alkyl. R' in Formula (III) is --H or --(C.sub.1 -C.sub.3)-alkyl, and Y' is --(C.sub.1 -C.sub.10)-alkyl, unsubstituted or substituted with --CO.sub.2 H, --OH, --NH--SO.sub.2 CF.sub.3, --SO.sub.3 H, --PO.sub.3 H.sub.2, --OSO.sub.3 H, --CF.sub.3, --F, ##STR2##
REFERENCES:
patent: 3016390 (1962-01-01), Counsell
patent: 3370070 (1968-02-01), Klimstra et al.
patent: 4220598 (1980-09-01), Hixson, Jr. et al.
patent: 4372888 (1983-02-01), Hjelmeland
patent: 4425273 (1984-01-01), Iida et al.
patent: 4514393 (1985-04-01), Castagnola et al.
patent: 4545938 (1985-10-01), Mosbach et al.
patent: 4550163 (1985-10-01), Voss et al.
patent: 4565811 (1986-01-01), DiSchiena
patent: 4771042 (1988-09-01), Braughler et al.
patent: 4793948 (1988-12-01), Hatono et al.
patent: 4966897 (1990-10-01), Angelastro et al.
patent: 4994443 (1991-02-01), Folkman et al.
patent: 5001116 (1991-03-01), Folkman et al.
patent: 5004737 (1991-04-01), Kim et al.
patent: 5039529 (1991-08-01), Bergendal et al.
patent: 5057509 (1991-10-01), Pellicciari et al.
patent: 5061701 (1991-10-01), Pellicciari et al.
patent: 5063222 (1991-11-01), Komoto et al.
patent: 5075464 (1991-12-01), Blohm et al.
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5192756 (1993-03-01), Zasloff et al.
patent: 5250524 (1993-10-01), Kramer et al.
K.S. Moore et al., "Squalamine: An aminosterol antibiotic from the shark," Proc. Natl. Acad. Sci. USA, vol. 90, Feb. 1993, pp. 1354-1358.
A.M. Bellini et al., "Antimicrobial Activity of Basic Cholane Derivatives Part IX," Arch. Pharm. (Weinheim), vol. 323, 1990, pp. 201-205.
A.M. Bellini et al., "Antimicrobial activity of basic cholane derivatives. X," Steroids, vol. 56, Jul. 1991, pp. 395-397.
J. McKenna et al., "Bis-steroids as Potential Enzyme Models," J.C.S. Chem. Comm., 1977, pp. 809-811.
S.L. Wehrli et al., "Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy," Steroids, vol. 58, No. 8, Aug. 1993.
A. Sadownik et al., "Rapid Construction of a Squalamine Mimic," Journal of the American Chemical Society, vol. 117, 1995, pp. 6138-6139.
R. Crum et al., "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment," Science, vol. 230, Dec. 20, 1985, pp. 1377-1378.
W. Auerbach et al., "Angiogenesis Inhibition: A Review," Pharmac. Ther., vol. 63, 1994, pp. 265-311.
A. Gagliardi et al., "Inhibition of Angiogenesis by Antiestrogens," Cancer Research, vol. 53, Feb. 1, 1993, pp. 533-535.
Moriarty, R.M., et al., "Synthesis of Squalamine. A Steroidal Antibiotic from the Shark," Tetrahedron Letters, vol. 35, No. 44, 31 Oct. 1994, pp. 8103-8106.
Collins Delwood C.
Frye Leah L.
Kinney William A.
Moriarty Robert
Zasloff Michael A.
Magainin Pharmaceuticals Inc.
Prior Kimberly J.
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