Method for inhibiting allograft rejection by the administration

Details Method for inhibiting allograft rejection by the administration Method for inhibiting allograft rejection by the administration

1994-02-14

1996-11-05

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 49, 514885, A61K 3170

Patent

active

055718000

ABSTRACT:
A method for suppressing the rejection of an allograft comprising administering azaribine at a time when the recipient of the allograft begins to mount a reject reaction against the allograft.

REFERENCES:
patent: 5023083 (1991-06-01), Drell
patent: 5200400 (1993-06-01), Teramoto et al.
American College of Rheumatology, 46th Annual Scientific Meeting, Atlanto, Georgia, Abstract Reproduction Form, cover sheet, 2-3, Table 1-3 (Oct. 1992).
Chen et al., "Mechanism of Action of the Novel Anticancer Agent 6-Fluoro-2' (2'-fluoro-1,1'-biphenyl-4-yl) -3-methyl-4-quinolinecarboxylic Acid Sodium Salt (NSC 368390): Inhibition of de Novo Pyrimidine Nucleotide Biosynthesis," Cancer Research 46 5014-5019 (Oct. 1986).
Drell, William, "Azaribine-Homocystinemia-Thrombosis in Historical Perspective", Pharmac. Ther., 41 195-206 (1989).
Elis et al., "Side Effects of 6-Azauridine Triacetate in Rheumatoid Arthritis," Clinical Pharmocology and Therapeutics, St. Louis, 11(3) 404-407, (May 1970).
Fischer et al., "Immunosuppression by Pyrimidine Nucleoside Analogs," Biochem. Pharmacol. 15 1013 (1966).
Havelka et al., "6-Azauridin-Triacetat in der Therapie de Chronischen Polyarthritis," Sonderdruck aus Zeitschrift f ur Rheumaforschung, 28(1/2) 29-35 (Jan./Feb. 1969).
Mathies, H., 109871p "Treatment of Rheumatic Illnesses with Immunosuppressive Substances," 15--Pharmacodynamics, Chemical Abstracts 74 230 (1971).
Raskova et al., 1435t "Unexpected Side-Effects of 6-Azauridine in Rheumatoid Arthritis and Feedback in Animal Experiments," Chemical Abstracts 77 60-61 (1972).
Sutton et al., "Drug Effects on Survival of Homografts of Skins," Archives of Surgery, pp. 840-843, vol. 87, Nov. 1963.

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