Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1984-04-12
1985-11-12
Kight, John
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
260112B, 260112R, 435 68, 435 69, 514 21, 514885, C07G 700
Patent
active
045527610
ABSTRACT:
The invention relates to SERUM-DERIVED "LEUKORECRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte recruitment from the bone marrow into the blood of animals and humans without biological side-reactions. The process for the production and isolation of leukorecruitin is characterized in that mammalian serum is subjected to regulated and limited proteolysis by contact activation, the protein is then separated from other foreign constituents and proteins of serum in the form of a crude serum protein concentrate fraction, and/or the protein is separated from other serum-proteins by chromatography on hydroxy-apatite. Leukorecruitin has very valuable pharmacological effects and can be used in compositions for specifically influencing the defense state of the animal or human body and for diagnostic purposes in hematological disorders.
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Kight John
Max-Planck Gesellschaft zur Forderung der Wissenschaften
Nutter Nathan M.
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