Method for induction of tumor cell apoptosis with chemical inhib

Details Method for induction of tumor cell apoptosis with chemical inhib Method for induction of tumor cell apoptosis with chemical inhib

1996-05-23

1999-01-19

Hollinden, Gary E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435 4, 435183, 435975, C12Q 126

Patent

active

058612688

ABSTRACT:
A method and test kit for determining tumor cell apoptosis by inhibition of 12-lipoxygenase is described. A method for selectively inducing tumor cell apoptosis by inhibiting 12-lipoxygenase is also described. The preferred compounds are selected from the group consisting of a cyclic hydroxamic acid; and an aryl aliphatic acid; nordihydro guaiaretic acid (NDGA) and N-benzyl-N-hydroxy-5-phenylpentanamide (BHPP).

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