Method for inducing rapid therapeutically effective antimalarial

Details Method for inducing rapid therapeutically effective antimalarial Method for inducing rapid therapeutically effective antimalarial

1977-01-21

1979-12-11

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424 38, 424263, 424330, A61K 3147, A61K 942, A61K 3144, A61K 31135

Patent

active

041783760

ABSTRACT:
Rapid therapeutically effective antimalarial levels of a member selected from the group consisting of 6,8-Dichloro-.alpha.-(dibutyl-amino-methyl-2-(3',4'-dichlorophenyl-4-quino linemethanol, 3-Dibutylamino-1-[2,6-bis(4-trifluoromethylphenyl)-4-pyridyl]propanol and 1,3-Dichloro-6-trifluoromethyl-9-[1-hydroxy-3-(dibutylamino) propyl]-phenanthrene are achieved by dissolving the same in an organic fatty acid of the formula: R-CCOH, wherein R represents a member selected from the group consisting of a saturated aliphatic hydrocarbon group of from seven to twenty carbon atoms and a mono-, di-, tri-, or tetra-unsaturated hydrocarbon group of from seven to twenty carbon atoms, and subsequently administering said acid containing the dissolved compound to a warm-blooded animal (e.g., human) afflicted with malaria.
Because of the extremely poor solubility of the above-described antimalarial compounds, therapeutically effective antimalarial blood levels of the same have only been able to be achieved when such compounds are administered around the clock for extended periods of time. The method of this invention substantially enhances the bioavailability of these compounds and thus permits rapid therapeutically effective antimalarial blood levels of the same to be achieved.

REFERENCES:
patent: 3082154 (1963-03-01), Allan
Chemical Abstracts 79:406t (1973)

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