Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-06-30
1989-02-28
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546153, 546159, 514313, A61K 3147, C07D21540
Patent
active
048085987
ABSTRACT:
This invention is directed to a method for inducing protection in an animal gainst poisoning resulting from exposure to toxic levels of cyanide comprising orally administering to said animal a therapeutically effective amount of a compound having the formula: ##STR1## wherein R represents ##STR2## R.sub.1 and R.sub.2 represent hydrogen, methyl or ethyl; R.sub.3 represent hydrogen, alkyl having 1 to 4 represents hydrogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R.sub.4 represents hydrogen or alkyl having 1 to 4 carbon atom; R.sub.5 represents hydrogen, alkyl having 1 to 7 carbon atoms, alkoxy having 1 to 7 carbon atoms, phenyl phenoxy, or substituted phenyl or phenoxy groups having the formula ##STR3## R.sub.6 represents hydrogen, alkyl having 1 to 4 carbon atoms, or alkoxy having 1 to 4 carbon atoms; R.sub.7 represents hydrogen, methyl or ethyl; R.sub.8 and R.sub.9 represent chloro, bromo, fluoro, trifluoromethyl or methoxy groups; n represents the integers 3,4,5,6 and 7; or pharmaceutically acceptable salts thereof wherein the salt forming acid or acid-hydrate is selected from the group consisting essentially of hydrochloric acid, phosphoric acid, nitric acid, sulfamic acid, sulfuric acid, maleic acid, fumaric acid, citric acid, beta-resorcylic acid and hydrobromic acid.
REFERENCES:
patent: 2719848 (1955-10-01), Geschickter et al.
patent: 3798322 (1974-03-01), Manning
patent: 4209519 (1978-03-01), Kinnamon
patent: 4302459 (1981-11-01), Steck et al.
Canfield Craig J.
Heiffer Melvin H.
Korte, Jr. Don W.
Adams William V.
Bellamy Werten F. W.
Higel Floyd D.
Lane Anthony T.
The United States of America as represented by the Secretary of
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