Method for inducing mydriasis in animals

Details Method for inducing mydriasis in animals Method for inducing mydriasis in animals

1985-01-08

1986-06-10

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514532, 514536, 514548, 514551, 514912, A61K 3122, A61K 3124, A61K 31225, A61K 31235

Patent

active

045943567

ABSTRACT:
A method of inducing short-term pupil diameter enlargement and reducing intraocular pressure in animals without significant systemic effects is disclosed. There is provided a site-specific chemical delivery method for topically applying to the eye of an animal, an effective ophthalmologically acceptable amount of an adrenalone diester of the general formula: ##STR1## wherein R prepresents a member selected from the group consisting of hydrogen or a C.sub.1 -C.sub.3 straight alkyl group; and wherein R.sub.1 and R.sub.2 independently represent an acyl group or derivative thereof; or an opthalmologically acceptable acid addition salt thereof. The method allows the pupil diameter to be enlarged for a short period after which the pupil returns to normal and thus restores normal eye sight.

REFERENCES:
patent: 3908017 (1975-09-01), Hussain et al.
patent: 3922348 (1975-11-01), Seidehamel et al.
patent: 4094983 (1978-06-01), Boder
Chem. Abst. 101, 183,396(e) (1984)-Bodor et al.

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