Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-07-28
2000-07-18
Degen, Nancy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4241841, 536 231, A61K 3100, A61K 3900, C07H 2104
Patent
active
060907916
ABSTRACT:
By injecting plasmid DNAs or oligonucleotides with DNA sequence containing a 2 base sequence of unmethylated cytosine and guanine adjacent thereto into mamalian mucosal cells, mucosal immunity and CD4 positive T cells capable of producing interleukin 10 and IFN-.gamma. can be induced.
REFERENCES:
patent: 5663153 (1997-09-01), Hutcherson et al.
Etchart et al. Class I-restricted CTL induction by mucosal immunization with naked DNA encoding measles virus haemagglutinin. J. Gen. Virol. 78: 1677-1580, 1997.
Ban et al. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine. 15 (8): 811-813, 1997.
Fynan et al. DNA vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations. PNAS. 90: 11478-11482, Dec. 1993.
David Pisetsky, "The Immunologic Properties of DNA," 421-423, 1996.
Sato Y., et al., "Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization," 1996, p. 352-354.
Roman et al, "Immunostimulatory DNA sequences function as T helper-1-promoting Adjuvants," 1997, p. 849-854.
Irisawa Atsushi
Kasukawa Reiji
Saito Ayako
Sato Yukio
Degen Nancy
Sato Yukio
Taisho Pharmaceutical Co. Ltd.
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