Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1997-06-30
2000-01-04
Witz, Jean C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435 724, C12N 508
Patent
active
06010905&
ABSTRACT:
The present invention relates to methods of increasing the antigen presenting ability of monocytes by contacting them with an agent which increases the intracellular calcium level. Methods of obtaining the monocytes are also disclosed. In addition, the present invention relates to methods of inducing bone marrow progenitor cells and endothelial cells to express molecules involved in generating immune responses. Methods of modulating the expression of molecules involved in generating immune responses are also disclosed, as are methods of treating cancer and leukemia.
REFERENCES:
patent: 4672044 (1987-06-01), Schreiber
patent: 5643786 (1997-07-01), Cohen et al.
Klein, J.B. et al., The J. of Immunology, vol. 144(11), pp. 4305-4311, Jun. 1990.
Nusselein, H.G. et al., Eur. J. Immunol., vol. 26(4), pp. 846-850, Apr. 1996.
Tyers, M. et al., FEBS LETT., vol. 206(1), pp. 99-105. (abstract only at this time), 1986.
Yonish-Rouach, E. et al., Cell. Immunol., vol. 134(2), pp. 402-413. (abstract only at this time), 1991.
Weber, C. et al., Eur. J. Immunol., vol. 23(4), pp. 852-859. (abstract only at this time), Apr. 1993.
Sigma BioSciences 1996 Cell Culture Catalogue and Price List, pp. 56-65, 1996.
Ina, Y. et al., The J. Immunol., vol. 139(5), pp. 1711-1717, Sep. 1987.
Gerli, R. et al., The J. of Immunol., vol. 142(8), pp. 2583-2589, Apr. 1989.
Cai, J.P. et al., Cell. Immunol., vol. 167(2), pp. 269-275, 1996.
Cohen, Peter et al., "Use of Interleukin-7, Interleukin-2, and Interferon-.gamma. to Propagate CD4.sup.+ T Cells in Culture with Maintained Antigen Specificity", Journal of Immunotherapy, 14 : 242-252 (1993).
De Boer, Martin et al., "Metabolic Comparison Between Basophils and Other Leukocytes From Human Blood", The Journal of Immunology, 136(9) : 3447-3454 (1986).
Esa, AH et al., "Immunological heterogeneity of human monocyte subsets prepared by counterflow centrifugation elutriation", Immunology, 59 : 95-99 (1986).
Freudenthal, Peter et al., "The distinct surface of human blood dendritic cells, as observed after an improved isolation method", Proc. Natl. Acad. Sci, USA, 87 : 7698-7702 (Oct. 1990).
Gieseler, Robert et al., "Dendritic accessory cells derived from rat bone marrow precursors under chemically defined conditions in vitro belong to the myeloid lineage", European Journal of Cell Biology, 54 : 171-181 (1991).
Kabel, Pieter et al., "Accessory Cells with a Morphology and Marker Pattern of Dendritic Cells can be Obtained from Elutriator-Purified Blood Monocyte Fractions. An Enhancing Effect of Metrizamide in this Differentiation", Immunobiol., 179 : 395-411 (1989).
Knight, Stella et al., "Non-adherent, low-density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology", Immunology, 57(4): 595-603 (1986).
Liu, Chengzheng et al., Biological Abstracts, 93(11):AB-686, No. 124808.
Liu, Chengzheng et al., "Phorbol Myristate Acetate and Calcium Ionophore A23187 Modulate the Accessory Cell Function of Mouse Dendritic Cells", Chin Med Sci Journal, 6(1): 18-23 (Mar. 1991).
Mehta-Damani, Anita et al., "Generation of Antigen-Specific CD8.sup.+ CTLs from Naive Precursors", J. Immunol., 153: 996-1003 (1994).
Ossevoort, Miriam et al., Dendritic Cells in Fundamental and Clinical Immunology, edited by Kamperdijk et al., Plenum Press, New York, NY, pp. 185-189 (Jul. 1993).
Ossevoort, Miriam et al., "A rapid isolation procedure for dendritic cells from mouse spleen by centrifugal elutriation", Journal of Immunological Methods, 155 : 101-111 (1992).
Peters, JH et al., "Differentiation of Human Monocytes into CD14 Negative Accessory Cells: Do Dendritic Cells Derive from the Monocytic Lineage?", Pathiobiology, 59 : 122-126 (1991).
Rober, Ruth-Ariane et al., "Induction of Nuclear Lamins A/C in Macrophages in in Vitro Cultures of Rat Bone Marrow Precursor Cells and Human Blood Monocytes, and in Macrophages Elicited in Vivo by Thioglycollate Stimulation", Experimental Cell Research, 190 : 185-194 (1990).
Romani, Nikolaus, et al., "Proliferating Dendritic Cell Progenitors in Human Blood", J. Exp. Med. 180 : 83-93 (Jul. 1994).
Spear, Gregory et al., "Oxidative Burst Capability of Human Monocyte Subsets Define by High and Low HLA-DR Expression", Immunological Investigations, 18(8): 993-1005 (1989).
Thomas, Ranjeny et al., "Comparative accessory cell function of human peripheral blood dendritic cells and monocytes," J. Immunol., 151(12): 6840-6852 (Dec. 1993).
International Search Report for PCT/US 98/13542, mailing date Mar. 17, 1999.
Dialog Information Service, File 154, Medline, Dialog accession No. 06943165, Medline accession No. 9123504, Gieseler RK et al:. "Dendritic accessory cells derived from rat bone marrow precursors under chemically defined conditions in vitro belong to the myeloid lineage", Eur. J. Cell Bio. (Germany) 54(1) : 171-181 (Feb. 1991).
Dialog Information Service, File 35, Dissertation Abstracts Online, Dialog accession No. 01501749, Shen, Hong Ming: "The Effects of Cocaine on Mouse Macrophage Biology (Calcium)", 57(04-B) of Dissertataion Abstracts International, p. 2467 (1996).
Dialog Information Service, File 154, Medline, Dialog accession No. 06925784, Medline accession No. 91347480, Liu C. et al.: "The enhancing effect of calcium ionophore A23187 on the accessory function of mouse dendritic cells", (China) 13(3), (1991).
Bernhard, H. et al., "Generation of Immunostimulatory Dendritic Cells from Human CD34+ Hematopoietic Progenitor Cells of the Bone Marrow and Peripheral Blood", Cancer Research 55:1099-1104, 1995.
Chengzheng, L. et al., Chinese Medical Sciences Journal, vol. 6(1), pp. 18-23, Mar. 1991.
Caux, C. et al., "Activation of Human Dendritic Cells through CD40 Cross-linking", J. Exp. Med. 180:1263-1272, 1994. Oct.
Caux, C. et al., "CD34.sup.+ Hematopoietic Progenitors from Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to GM-CSF+ TNF.alpha.", J. Med. Exp. 184:695--706, 1996. Aug.
Flores-Romo, L. et al., "CD40 Ligation on Human Cord Blood CD34.sup.+ Hematopoietic Progenitors Induces Their Proliferation and Differentiation into Functional Dendritic Cells", J. Exp. Med. 185:341-349, 1997 #12, Jan.
Hsu, F.J. et al., Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells, National Medicine 2:52-58, 1996, #1 Jan.
Klaus, G. et al., "Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca.sup.++ -dependent, FK506-sensitive pathway", Eur. J. Immunol. 24:3229-3232, 1994.
Nijman, H.W. et al., Antigen Capture and Major Histocompatibility Class II Compartments of Freshly Isolated and Cultured Human Blood Dendritic Cells, J. Exp. Med. 182:163-174, 1995, Jul.
Nishioka, Y. et al., "The Role of CD40-CD40 Logand Interaction in Human T Cell--B Cell Collaboration", J. Immunol. 153:1027-1036, 1994.
Pickl, W.F. et al., "Molecular and Functional Characteristics of Dendritic Cells Generated from Highly Purified CD14.sup.+ Peripheral Blood Monocytes", J. Immunol. 157:3850-3859, 1996.
Peters, J. H. et al., "Dendritic cells: from ontogenetic orphans to myelomonocytic descendants", Immunol. Today 17:273-278, 1996, Jun.
Seino, K. et al., "CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4.sup.+ T cells" Int. Immunol. 7:1331-1337, 1995.
Szaboles, P. et al., "Dendritic Cells and Macrophages Can Mature Independently From a Human Bone Marrow--Derived, Post--Colony-Forming Unit Intermediate", Blood 87:4520-4530, 1996. #11 Jun.
Thomas, R. et al., "Isolation and Characterization of Human Blood Peripheral Blood Dendritic Cells", J. Immunol. 150:821-834, 1993, #3 Feb.
Thomas, R. et al., "Human Peripheral Blood Dendritic Cells Subsets" J. Immunol. 153:4016-4028, 1994.
Zhou, L. et al., "CD14.sup.+ blood monocytes can differentiate into functionally mature CD83.sup.+ dendritic cells", Proc. Natl. Acad. Sci. U.S.A. 93:2588-2592, 1996. Mar.
Carter Charles
Cohen Peter A.
Czerniecki Brian J.
Koski Gary K.
Ojeifo John O.
The United States of America as represented by the Department of
Witz Jean C.
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