Method for inducing death of neoplastic cells using piperazne de

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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A61K 31495, A61K 3150

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active

057339112

ABSTRACT:
A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrrolidinedione-1-alkoxyl (C1-4), or ##STR2## wherein X.sup.1 is a chemical bond or C1-2 alkylene, X.sup.2 is hydrogen or carboxyl forming a 5-membered ring with X.sup.1 when X.sup.2 is methylene, X.sup.3 is hydrogen or C1-2 alkyl, X.sup.4 is hydrogen or C1-2 alkyl, or X.sup.3 and X.sup.4 together form a 5-membered ring, in which at least one of X.sup.2, X.sup.3, and X.sup.4 is hydrogen,

REFERENCES:
patent: 4333879 (1982-06-01), Tamai et al.
patent: 4382889 (1983-05-01), Tamai et al.
patent: 4418075 (1983-11-01), Tamai et al.
patent: 4474800 (1984-10-01), Tamai et al.
patent: 4507297 (1985-03-01), Masaki et al.
patent: 4596803 (1986-06-01), Masaki et al.
patent: 4732910 (1988-03-01), Yaginuma et al.
patent: 5214056 (1993-05-01), Haruta et al.
patent: 5336783 (1994-08-01), Omura et al.
patent: 5422359 (1995-06-01), Ando et al.
Kamiya Biomedical Co., catalogue, winter, 1995.
Cell Biology, vol. 63, pp. 146-150, Jan. 1988, Yoko Shoji-Kasai, Mitsuko Senshu, Shintaro Iwashita and Kazutomo Imahori.
Science vol. 267, pp. 1456-1462, Mar. 10, 1995, Craig B. Thompson.
Biochemical and Biophysical Research Communication vol. 214, No. 3, pp. 1130-1137, Sep. 25, 1995, Wen Zhu, Patricia E. Murtha and Charles Y. F. Yong.
Histol Histopathol (Spain), 9 (3) P485-493, ISSN 0213-3911, Jul. 1994, Logothetou-Rella.
Abstract, Piperazine derivatives as oral thiol protease inhibitors, Japanese Patent No. JP63275575, Mitsuo Mazaki, et al. (1987).

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