Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2000-11-28
2002-01-01
Jarvis, William R. A. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S650000
Reexamination Certificate
active
06335371
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates in general to a method for inducing cognition enhancement in a mammal. More particularly, the invention relates to a method for inducing cognition enhancement in a mammal by administering to the mammal an effective amount of 1,7,7-trimethylbicyclo[2.2.1]heptane derivative of Formula I
wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.
The present invention also relates to a method of treating cognitive impairment in a mammal, such as, but not limited to the cognitive impairment associated with somatic diseases, psychiatric disorders and aging by administering to the mammal an effective amount of the compound of formula (I) or a pharmaceutically acceptable salt thereof.
Additional objects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objects and advantages of the invention will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims.
BACKGROUND OF THE INVENTION
The active ingredients of this invention, (1R,2S,4R)-(−)-2-phenyl 2-(dimethylaminoethoxy)-1,7,7-trimethyl-bicyclo[2.2.1]heptane, known as deramciclane, and (1R,2S,4R)-(−)-2-phenyl-2-(methylaminoethoxy)-1,7,7-trimethyl-bicyclo[2.2.1]heptane, known as N-desmethylderamciclane, and their pharmaceutically acceptable acid addition salts with inorganic and organic acids generally used for the purpose, fall within the disclosures of U.S. Pat. No. 4,342,762 and International Patent Application No. WO 98/17230, respectively, which are both incorporated herein by reference.
These compounds are selective serotonin 5HT2A- and/or 5HT2C-receptor antagonists. They have shown anxiolytic-like effects in animal test models.
DESCRIPTION OF THE INVENTION
Applicants have surprisingly discovered that the compounds of formula (I) do induce cognition enhancement in a mammal. Accordingly, an object of the present invention is a method for inducing cognition enhancement in a mammal by administering to the mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. In addition, the present invention provides a method of treating cognitive impairment in a mammal associated with somatic diseases, psychiatric disorders and aging by administering to the mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Somatic diseases, such as but not limited to dementias (e.g. Lewy body dementia, vascular dementia, Alzheimer's Disease, and HIV associated dementia) and Parkinson's Disease, are associated with serious impairment in cognitive function. Cognitive impairment is related also to several psychiatric disorders, especially to affective disorders (e.g. depression, psychotic disorders, such as schizophrenia) and anxiety disorders. Anxiety disorders include but are not limited to Generalized Anxiety Disorder (GAD), Obsessive Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), Social Anxiety Disorder (SAD), Panic Disorder (PD), agarophobia, and Attention Deficit Hyperactivity Disorder (ADHD). In addition, cognition impairment is caused by several disorders associated with aging, such as Age Associated Memory Impairment. Further, cognitive impairment is often related to the usage of drugs, such as benzodiazepines and tricyclic antidepressants, which are common in the treatment of different somatic diseases and psychiatric disorders.
For the purposes of this disclosure and claims the term “treatment” is relating to treatment in order to cure or alleviate the disease or its symptoms, and to treatment in order to prevent the development or the exacerbation of the disease or its symptoms.
Pharmaceutically acceptable salts of the compound of Formula (I) can be formed with inorganic acids, e.g. hydrohalogenic acid such as hydrochloride acid or hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid, or organic acids e.g., tartaric acid, succinic acid, maleic acid, maleic acid, fumaric acid, citric acid, or lactic acid. Salt with fumaric acid is preferred.
Pharmaceutical compositions containing a compound of Formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient include the usual oral dosage forms, such as tablets, capsules, and liquid preparations. In oral dosage forms, the active ingredient can be mixed with suitable pharmaceutically acceptable excipients, such as starch, lactose, sucrose and magnesium stearate, in accordance with conventional pharmaceutical practice.
The precise amount of the drug to be administered to a mammal for inducing cognition enhancement and for the treatment of cognitive impairment is dependent on numerous factors known to one skilled in the art, such as the compound to be administered, the general condition of the patient, the condition to be treated etc. For example, the usual recommended oral daily dose of deramciclane would be about 5-150 mg/day, preferably 30-60 mg/day.
The invention will be further clarified by the following example, which is intended to be purely exemplary of the invention.
REFERENCES:
patent: 5652270 (1997-07-01), Budai et al.
Bojiti et al., “Pharmacokinetics of deramciclane in dogs”, Pharmaceutical Sciences, vol. 3, pp. 503-506 (1997).
Csala et al., “Decrease of gluconeogenesis by deramciclane is counteracted by cytochrome P450 inhibitors”, Pharmaceutical sciences, vol. 3, pp. 469-472 (1997).
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Kanerva H., “Pharmacokinetic studies on deramciclane”, Kuopio, Department of Pharmaceutics, University of Kuopio (1999).
Kanerva et al., “Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing”, Biopharmaceutics and Drug Disposition, vol. 19, pp. 531-539 (1998).
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Bilkei-Gorzo et al., “mCPP-induced anxiety in the light-dark box in rats—a new method for screening anxiolytic activity”, Psychopharmacology (Berl), vol. 136, pp. 291-298 (1998).
Borden et al., “Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site”, Receptors and channels,
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Jarvis William R. A.
Orion Corporation
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