Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-04-21
1998-12-01
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514826, A61K 31135
Patent
active
058440020
ABSTRACT:
The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.
REFERENCES:
patent: 5362755 (1994-11-01), Barberich et al.
patent: 5547994 (1996-08-01), Barberich et al.
patent: 5760090 (1998-06-01), Barberich et al.
Tan et al. "Stereoselective Disposition of Salbutamol Enantiomers . . . " Clin. Chem. 33, 1026 (1987).
Brittain et al. "Some observations on the .beta.-adrenoceptor agonist . . . " Br. J. Pharmac. 48, 144-147 (1973).
Hartley et al. "Absolute Configuration of the Optical Isomers of Salbutamol" J. Med. Chem. 12, 995 (1971).
Hawkins et al. "Relative Potency of (-)-and (.+-.)-Salbutamol on Guinea Pig . . . " J. Med. Chem. 16, 856-857 (1973).
Buckner et al. "Studies on the Effects of Enantiomers of Soterenol, Trimetoquinol . . . " J. Pharm. Exp. Ther. 189, 616-625 (1974).
Passowicz-Muszynska E. "Effect on beta adrenergic receptors of tachyphylaxis . . . " Index Medicus 91:164287.
Pauwels "Effect of corticosteroids on the action of sympathomimetics" Index Medicus 86:051970.
Chapman et al. "An anomalous effect of salbutamol in sensitised guinea pigs" Brit. J. Pharmacol 99, 66P (1990).
Morley et al. "Effects of (+) and racemic salbutamol on airway responses in the guinea pig" Brit. J. Pharmacol. 104, 295P (1991).
Chapman et al. "Racemic mixtures at root of worsening symptoms? Active enantiomers . . ." TIPS 13, 231-232 (1992).
Muittari et al. "Comparison of acute bronchodilator effects of oral salbutamol, . . . " Chem. Abstr. 89: 123259m (1978).
Barberich Timothy J.
Young James W.
Henley III Raymond
Sepracor Inc.
LandOfFree
Method for inducing bronchodilation using optically pure R(-) al does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for inducing bronchodilation using optically pure R(-) al, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inducing bronchodilation using optically pure R(-) al will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2396121