Method for inducing apoptosis of primary central nervous system

Details Method for inducing apoptosis of primary central nervous system Method for inducing apoptosis of primary central nervous system

1997-11-14

2000-03-28

Huff, Sheela

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241331, 4241351, 4241431, 4241441, 424 851, 424 852, 424 854, 5303873, 5303881, 53038822, 514 12, A61K 39395, A61K 3816, C12P 2108, C07K 1600

Patent

active

060428260

ABSTRACT:
A method for treating a primary central nervous system lymphoma in an individual relates to administering intrathecally or intralesionally a therapeutically effective amount of a Fas-cross-linking composition thereby inducing the lymphoma cells to undergo Fas-mediated cytotoxicity. The Fas-cross-linking composition may be an agonist anti-human Fas monoclonal antibody or fragments thereof, soluble Fas-ligand (Fas-L), and a combination thereof. In another embodiment, the lymphoma is pretreated with a composition that enhances Fas-mediated cytotoxicity induced by a Fas-cross-linking composition, followed by treatment with the Fas-cross-linking composition.

REFERENCES:
Leithauser et al., "Constitutive and Induced Expression of APO-1 . . . " Laboratory Investigation, 1993, vol. 69, No. 4, p. 415.
Dhein et al., "Induction of Apoptosis by Monoclonal Antibody Anti-APO-1 Class Switch Variants is Dependent on Cross-Linking of APO-1 Cell Surface Antigens", The Journal of Immunology, 1992, vol. 149, No. 10, p. 3166.

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